Hydroxysafflor yellow A - Chemical & Pharmaceuticals - Pharmaceutical

Hydroxysafflor yellow A is a flavonoid derived. It is extracted from traditional Chinese medicine Carthamus tinctorius L. It possesses anti-tumor activity. It could inhibit LPS-induced VSMCs proliferation and migration, and inhibited LPS-induced upregulation of TLR-4 expression in vitro. It attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. It inhibited the proliferation of 3T3-L1 preadipocytes and cell viability greatly decreased in a dose and time dependent manner. It inhibited adipogenesis by increasing HSL promoter activities. It can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacity and inhibiting the expression of TGF-β. It prevents steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells.