PLGA - Polymeric Nanoparticles Copolymer for Cancer Therapy - Medical / Health Care

PLGA nanospheres have already been successfully used in vitro and in clinical trials. Results show that drugs encapsulated in PLGA nanoparticles have superior accumulation in the tumor environment, reduced tumor size and enhanced inhibition of cell proliferation. This is thanks to increased cell penetration and reduced toxicity of encapsulated compounds. Because of the higher accumulation in tumoral areas PLGA nanoparticles are also useful for cancer diagnosis and imaging which has a key role in clinical oncology to early detection and accurate prognosis. The greater therapeutic index of encapsulated paclitaxel, cisplatin and mitoxantrone among other chemotherapy drugs over their equivalent clinical counterparts has been proved multiple times.