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Biolojic Design, Ltd.
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  5. Epitope Specific Case Study

Epitope Specific Case Study

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Oct. 31, 2018
Courtesy ofBiolojic Design, Ltd.
Published example: Computationally designed epitope specific Multibody binding a cryptic epitope
  • Challenge: Designing an Ab for a cryptic epitope - not exposed to solvent in the native conformation*
  • N terminus covers epitope in the native conformation and desired binding site (epitope) is hidden
  • Biolojic’s solution - epitope specific Antibody which moves the N terminus and binds at the desired site, leading to the desired biological effect

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“Biolojic […] announced that it has entered into a research collaboration and license option agreement with Nektar Therapeutics to discover and develop agonistic antibodies that activate a novel and previously un-drugged target for the treatment of autoimmune disease.”