Animal Injection Articles & Analysis: Older
4 articles found
Despite international treaties, the use of chemical weapons remains a concern nowadays. Organophosphorus-nerve agents (OPs) act by inhibiting cholinesterases (ChE), preventing the degradation of some neurotransmitters. Their excessive accumulation can impair neuronal transmission, leading to cholinergic syndrome, which can cause symptoms such as respiratory failure and, in severe cases, death. ...
l The hind paw of the experimental animal was given a concentrated radiant heat stimulus and the animal was free to change position at any time to avoid the stimulus. ...
In addition, these compounds also exhibited an increase in the fluorescently labeled DiI-LDL uptake in the nanomolar rangein situ. Furthermore, in a two week animal study, subcutaneous injection of 4 mg/kg of one of these compounds resulted in a 32% reduction of the total cholesterol level in mice fed a high fat/high cholesterol diet as compared to 27% ...
Furthermore, these compounds exhibited a 5- to 10-fold LDLR upregulation at 1.6 μM in two recombinant cell-based assays as well as exhibited an increase in the fluorescently labeled DiI-LDL uptake in situ in the nanomolar range. In animal studies, intraperitoneal (IP) injection of these compounds administered alone resulted in more than 20% reduction in LDL-C ...