Cell Cycle Dna Damage Articles & Analysis: Older
4 articles found
The cell cycle is an essential biological process that enables cells to grow, duplicate their DNA, and divide into daughter cells. ...
Post-translational modifications (PTMs) of histones are crucial for protein structure regulation, playing key roles in gene expression regulation, DNA repair, cell signaling, and more. These PTMs of histones can be achieved by adding or removing different chemical groups or proteins, thus affecting chromatin structure and function. ...
It binds to key targets such as microtubules or genomic DNA to inhibit tumor cell proliferation. In order to develop more effective payloads, a number of relevant studies are under way, which can be optimized from three aspects: physical and chemical properties, load quantity and new loads. ...
Abstract The oncogene Ras and the tumor suppressor gene p53 are frequently co-mutated in human cancer and mutations in Ras and p53 can cooperate to generate a more malignant cell state. To discover novel druggable targets for cancers carrying co-mutations in Ras and p53, we performed arrayed, kinome focused siRNA and oncology drug phenotypic screening utilizing a set of ...