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Cell Imaging Articles & Analysis: Older
32 articles found
In the vascular system, LPA production promotes endothelial cell migration and angiogenesis. Knockout studies in mice reveal impaired vessel formation and developmental defects, underscoring ENPP2’s importance in vascular biology. ...
Understanding Plant Cell Viability Plant cells, like all living cells, undergo a complex cycle of growth, differentiation, and death. ...
The incorporation of computer algorithms facilitates the extraction of meaningful data from images, enabling more consistent and reproducible results. Techniques in Histological Image Analysis Histological image analysis employs several methodologies, each catering to specific aspects of tissue examination: Image Acquisition: ...
By integrating a reporter gene into the genome of a cell, researchers can create a stable cell line that emits a measurable signal in response to specific stimuli or conditions. ...
Understanding the Cytoskeleton The cytoskeleton consists of three main types of filaments: Microfilaments (Actin Filaments): Involved in muscle contraction, cell movement, and cytokinesis. Intermediate Filaments: Provide structural support and stability, connecting cells through desmosomes and hemidesmosomes. ...
Key techniques include multi-omics profiling, immune checkpoint blockers (ICBs), RNA-sequencing (RNA-Seq), single-cell analysis, imaging mass cytometry (IMC), and multiplexed ion beam imaging (MIBI). ...
Currently, DNA constructs encoding fluorescent proteins fused to LC3 are widely employed for introduction into cells for monitoring autophagosome formation by fluorescence microscopy. ...
Dendrimers have attracted much attention in drug delivery, imaging, and materials science due to their unique structure, high monodispersity, and tunable properties. ...
This blog aims to provide insights into apoptosis assays, their methodologies, and their significance in understanding the mechanisms underlying cell death. Understanding Apoptosis Apoptosis is a programmed form of cell death that eliminates damaged or unwanted cells from the body. ...
Copper-Free Click Chemistry for Clickable Drug Surrogates Copper-free click chemistry has presented intriguing opportunities for the development of clickable drug surrogates, particularly in the context of fluorescent imaging of target of interest (TOI) proteins within live cells. The small molecular size of the tag for click chemistry allows known ligands to be ...
MSCs exhibit specific morphology, which makes them unique compared to other cell types typically used in CLD. While forming spindle-shaped, elongated, and transparent cell projections, the MSCs can pose a significant challenge when it comes to imaging and subsequent image analysis. Many imaging systems ...
CD BioSciences, a US-based biotechnology company focusing on the development of imaging technology, has announced the launch of its innovative line of Chromogenic Substrates for immunohistochemistry (IHC). ...
Another researcher incubated fluorescent microspheres with vancomycin, combined with the ligase on the bacterial cell wall through hydrogen bonds and effectively identified live or dead bacteria in solution through the diffusion of fluorescent magnetic bead microspheres. ...
For example, human immune cells have a class of carbohydrate-binding receptors called SIGLEC that can bind sialoglycan. ...
There are a ton of practical uses for computer vision at present times. One industry where this technology is increasingly useful in healthcare. It is impossible to exaggerate the value of computer vision services in the medical field. Its methods continue to be used more widely since they have demonstrated excellent utility in numerous medical contexts, including surgical planning and medical ...
First, I knew the science very deeply: the plan was to make use of the software my lab had created and open-sourced, called CellProfiler, to extract features from images. They would also use the image-based profiling assay my lab co-invented with Stuart Schreiber’s team, called Cell Painting, which uses cells’ ...
How could we take a less biased approach? Could we use images of human cells and computer vision approaches to turn those images into sophisticated omics data unveiling broad, deep and complex biological systems? ...
Assay for transposase-accessible chromatin using sequencing (ATAC-seq) was developed and was further applied to single cells9,10. Imaging chromatin accessibility in fixed cells using fluorescence-labelled DNA oligomers assembled in Tn5 (ATACsee)11 suggests that it is feasible to profile chromatin accessibility in situ. ...
However, nuclei detection and segmentation of FISH slides through microscopic images is tedious and time-consuming for pathologists to evaluate. Furthermore, FISH specimen slides provided at pathological laboratories are frequently noisy and not analyzable entirely. ...
An adaptive thresholding method followed by a watershed segmentation algorithm is employed to segment cells of interest areas. Furthermore, analyzable cells are found and nondetectable cells because of cell overlapping or image staining are discarded. ...