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Cholesterol High Articles & Analysis: Older

9 articles found

Diabetes: Medications, Treatments, and Remedies

Diabetes: Medications, Treatments, and Remedies

While there is the potential for dangerous side effects from insulin, including hypoglycemia, ketoacidosis, and high cholesterol, careful blood sugar monitoring can greatly reduce the risk and ease your mind that insulin can be safely taken. ...

ByGenteel LLC


3 tips to improve cardiovascular health

3 tips to improve cardiovascular health

Consuming too many unhealthy fats (saturated and trans fats) can cause high cholesterol, which increases the chance of coronary artery disease. When cholesterol is too high, plaque can build up in the arteries—putting you at higher risk for heart attack and stroke. ...

ByEvidation


Innovation Spotlight: Alucent Biomedical | Can we Make ‘Stents’ Obsolete?

Innovation Spotlight: Alucent Biomedical | Can we Make ‘Stents’ Obsolete?

Affecting eight to 10 million people in the U.S., and 200 million people worldwide[i], PAD’s primary risk factors include obesity, high cholesterol, hypertension, diabetes and tobacco use. The prevalence of PAD rises with age, from five percent at age 60 to 20 percent at age 80. ...

ByAlucent Biomedical Inc.


Nonalcoholic Fatty Liver and How Fucoxanthin Might Help

Nonalcoholic Fatty Liver and How Fucoxanthin Might Help

As mentioned above, NAFL tends to develop in people who are overweight or obese or have diabetes, high cholesterol or high triglycerides. Rapid weight loss and poor eating habits also may lead to non-alcoholic fatty liver. ...

ByAlgatech


Duplicating the conditions of the body - Case Study

Duplicating the conditions of the body - Case Study

For centuries, folklore has recognized that garlic is a cure-all, preventing heart disease, high cholesterol, diabetes, and high blood pressure. With the help of Sierra, Dr. ...

BySierra Instruments, Inc.


Abstract 9761: Novel Modulators of Low Density Lipoprotein Receptor Metabolism

Abstract 9761: Novel Modulators of Low Density Lipoprotein Receptor Metabolism

Abstract Intervention with drugs to reduce Low Density Lipoprotein-cholesterol (LDL-C) has proven to decrease the risk of subsequent cardiovascular events, including mortality. ...

ByShifa Biomedical Corporation


121 - Development of Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists

121 - Development of Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists

In addition, P-4 exhibited over 20% reduction in LDL-C when administered at 10 mg/kg orally to mice fed a high fat/high cholesterol diet. This study focused on the development of P-4 as a preclinical candidate for an IND filling. ...

ByShifa Biomedical Corporation


Abstract 15053: New Insights into the Development of the Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists

Abstract 15053: New Insights into the Development of the Protease Proprotein Convertase Subtilisin-Like Kexin Type 9 Antagonists

In vivo pharmacological evaluation revealed that subcutaneous injection of 3 mg/kg of this antagonist resulted in a 25% reduction in LDL-C levels in mice fed a high fat/high cholesterol diet. Moreover, administration of 5 mg/kg of the inflammatory mediator lipopolysaccharide (LPS) resulted in an upregulation of the PCSK9 level associated with a ...

ByShifa Biomedical Corporation


Abstract 10306: Identification and Characterization of Orally Bioavailable Small Molecule Protease Proprotein Convertase Subtilisin-like Kexin Type 9 Inhibitors (Best of Basic Science Abstract)

Abstract 10306: Identification and Characterization of Orally Bioavailable Small Molecule Protease Proprotein Convertase Subtilisin-like Kexin Type 9 Inhibitors (Best of Basic Science Abstract)

Abstract Intervention with drugs to reduce low density lipoprotein-cholesterol (LDL-C) has proven to decrease mortality and morbidity. Here, we report the development of small molecules that lower LDL-C by targeting the LDL-receptor (LDLR) degradation pathway, which is modulated by the protease proprotein convertase subtilisin-like kexin type 9 (PCSK9). ...

ByShifa Biomedical Corporation

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