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Cll Leukemia Articles & Analysis: Older

4 articles found

Understanding the BCL2 Gene Family: Function, Research Highlights, and Medical Relevance

Understanding the BCL2 Gene Family: Function, Research Highlights, and Medical Relevance

A major breakthrough occurred with the FDA approval of Venetoclax (ABT-199), a BCL2-selective inhibitor used in the treatment of chronic lymphocytic leukemia (CLL). Venetoclax works by mimicking BH3-only proteins, thereby displacing pro-survival BCL2 proteins and triggering apoptosis in cancer cells. In 2020, a study published in the New England Journal of ...

ByCreative BioMart


Tackling Barriers to MRD Adoption in the Community Setting

Tackling Barriers to MRD Adoption in the Community Setting

ACCC just launched updates to the MRD Testing Implementation Roadmap, which aims to help multidisciplinary providers successfully integrate MRD testing into the cancer care continuum for patients with Chronic Lymphocytic Leukemia (CLL) and multiple myeloma, complementing the Roadmap for patients with B-cell acute lymphoblastic leukemia (ALL) ...

ByAdaptive Biotechnologies


Whatever Happens, the Patient Has to be at the Center

Whatever Happens, the Patient Has to be at the Center

Shannon Fatigante (Talent Acquisition Senior Program Manager) has a father currently fighting chronic lymphocytic leukemia (CLL). Shannon: When my dad called me last summer, he very calmly shared that his recent bloodwork had revealed that he had cancer – specifically CLL. ...

ByAdaptive Biotechnologies


A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia (Clinical Cancer Research)

A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia (Clinical Cancer Research)

Purpose:Although considerable progress has been made withautologous T cell–based therapy in B-cell malignancies, appli-cation in chronic lymphocytic leukemia (CLL) lags behind dueto disappointing response rates as well as substantial toxicitythat is of particular concern in the elderly CLL population.Vg9Vd2-T cells form a conserved T-cell ...

ByLAVA Therapeutics N.V.

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