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Disease Under Researched Articles & Analysis: Older
106 articles found
Lipids are not merely structural components of cellular membranes—they also act as powerful signaling molecules that orchestrate key physiological processes. Among the enzymes regulating lipid signaling, ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2), also known as autotaxin, plays a central role by converting lysophosphatidylcholine (LPC) into the bioactive lipid ...
In recent years, the field of antibody drug design has become increasingly significant in the realm of therapeutic development, driven by the need for more effective and targeted treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases. Antibodies, which are proteins produced by the immune system, have the ability to specifically recognize and bind to ...
Cytokines are small proteins that play a crucial role in cell signaling, particularly in the immune system. They regulate inflammation, immunity, and hematopoiesis, making them essential for understanding various biological processes and disease mechanisms. For researchers working with rabbit models, the ability to accurately measure cytokine levels is vital. This is where Customized Rabbit ...
Podocytes are specialized epithelial cells located in the kidneys, playing a crucial role in the filtration barrier of the glomerulus. These unique cells have garnered significant attention in scientific research due to their pivotal function in maintaining kidney health and their involvement in various kidney diseases. The Structure and Function of Podocytes Podocytes possess a distinct ...
The quest for effective therapeutics begins long before a drug reaches clinical trials. One of the cornerstones of this process is drug screening in animal models, which plays a pivotal role in evaluating the safety and efficacy of potential treatments. Animal models offer researchers valuable insights that cannot be obtained through in vitro studies alone, bridging the gap between laboratory ...
The study of cardiovascular biology is essential for understanding the mechanisms that regulate heart function and vascular health. As cardiovascular diseases remain the leading cause of death worldwide, advancements in this field offer crucial insights for developing new treatments and preventive strategies. Understanding the Cardiovascular System The cardiovascular system comprises the heart, ...
Nicotinamide adenine dinucleotide (NAD) and its reduced form (NADH) are essential coenzymes involved in a wide array of cellular metabolic processes. As critical mediators in oxidation-reduction (redox) reactions, NAD/NADH plays a pivotal role in energy production and cellular metabolism. Understanding and analyzing these biomolecules has become increasingly important in areas such as disease ...
Disease Research: By mapping altered flux patterns in cancer cells, cardiovascular diseases, or diabetes, MFA helps identify potential metabolic vulnerabilities or biomarkers for diagnosis and therapy. ...
Knockin cell line generation represents a pivotal advancement in genetic engineering, providing vital tools for biological research and therapeutic development. This process involves the integration of specific DNA sequences into precise loci within the genome, allowing scientists to explore gene function, model diseases, and develop new treatments. Understanding Knockin Cell Line Generation At ...
As we step into 2024, the global health landscape is increasingly focused on combatting viral infections, which continue to pose significant threats to public health. The COVID-19 pandemic has illuminated the critical need for innovative strategies in antiviral research, and scientists worldwide are embarking on groundbreaking projects to develop more effective therapies, vaccines, and preventive ...
In the quest to unravel the complexities of infectious diseases, understanding the intricate interplay between pathogens and their hosts is paramount. This requires a comprehensive analysis of gene expression and the regulatory mechanisms at play during infection. Traditional RNA sequencing (RNA-seq) has long been employed to investigate the gene expression profiles of microbial pathogens. ...
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in the regulation of gene expression. Their ability to modulate various biological processes makes them significant players in the field of molecular biology and medicine. Among the various tools utilized in research and therapeutic applications, miRNA mimics have emerged as powerful instruments for manipulating and ...
It plays a crucial role in ocular research, particularly for studies related to corneal physiology, wound healing, and the pathogenesis of various ocular diseases. ...
Skeletal muscle microvascular endothelial cells (SMECs) play an essential role in maintaining muscle function, metabolism, and overall health. These specialized cells line the blood vessels within skeletal muscles, forming a barrier that regulates the exchange of substances between the bloodstream and muscle tissue. Their significance extends beyond mere structural support; they actively ...
Collagen is an important structural protein that is widely found in various biological tissues, such as skin, bones, tendons, and blood vessels. Accurate determination of collagen content is very important for biomedical research, disease diagnosis and quality control of related products. Here are some commonly used methods for determining collagen content.ChromatographyHigh-performance liquid ...
Therefore, the detection of sialic acid proteins holds significant value in disease diagnosis, biomedical research and drug development.Biological Importance of Sialic Acid ProteinsSialic acid proteins play an indispensable role in many physiological and pathological processes. ...
In biomedical research, the detection and analysis of biomarkers are crucial. Among them, glycoproteins are an essential biomarker that plays a key role in many biological processes, including disease onset, progression, and treatment response. The Tandem Affinity Purification (TAP) of glycoprotein is an efficient detection method.What Is a Glycoprotein?Firstly, let's understand what a ...
Mitochondria are a unique type of organelle present within cells, serving as the primary source of energy within living organisms. They are responsible for several life-sustaining processes, including energy production, reducing free radicals, and maintaining cellular signaling. Proteins within the mitochondria play a key role in these processes.Why Sequence Mitochondrial Proteins?The sequencing ...
What is Gene Knockout Technology?Gene knockout (Gene Knockout) is a molecular biology technique that allows researchers to block or shut off the function of a specific gene to study its role and importance. This technique is achieved by introducing mutations into the gene, making it impossible for the gene to express properly or produce functional proteins.Applications of Gene Knockout ...
Protein SequencingProtein sequencing helps to accurately analyze the amino acid sequence and three-dimensional structure of disease-related proteins, and then reveal their biological functions and interaction mechanisms, providing potential targets for new drug research.2. ...