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Drug Therapy Treatment Articles & Analysis: Older
51 articles found
Many oncology drugs have been abandoned by pharmaceutical companies due to poor performance in phase I, II, or III clinical trials. These drugs represent untapped potential treatments for indications outside of those initially investigated. With research and development costs for a single new drug estimated between $2–3 billion, abandoned drugs represent an opportunity to bring drugs to ...
Notable examples include peptide hormones like insulin and drugs used in cancer treatment. Vaccines Synthetic peptides are employed in the development of vaccines, providing a safe and stable alternative to traditional attenuated or inactivated pathogens. ...
In epigenomics experiments, the use of parallel samples is to ensure the reliability and repeatability of experimental results. The choice of the number of parallel samples depends on various factors, including experimental design, expected variability, data analysis methods, etc. Here are some specific examples to illustrate the selection of the number of parallel samples in different ...
These antibodies may reduce the effectiveness of the drug and even cause adverse reactions.Applications1. BiologicsFor biologic drugs (such as monoclonal antibodies or protein-based therapies), patients may develop anti-drug antibodies (ADA), which can neutralize the potency of the drug or accelerate its ...
Ongoing research and inventions in the field of oncology focus on the development of small molecule drug therapies for use in brain tumor resection. Small molecule drugs are being developed to target and effectively treat brain tumors to improve therapeutic outcomes. ...
In the grand symphony of life, there are countless unsung heroes quietly orchestrating the countless chemical reactions that sustain our world. These remarkable biomolecules, known as enzymes, are the true MVPs (Most Valuable Proteins) that keep our planet thriving. Enzymes are nature's own specialized workforce, each one tailored to catalyze a specific reaction. Imagine a team of highly ...
SN38-BSA is a bioconjugate product that is effectively revolutionizing the field of drug delivery. This article focuses on understanding its makeup and how bioconjugation is instrumental in its function and efficacy. To begin with, SN38-BSA is composed of SN38, a potent anti-cancer drug, and BSA or Bovine Serum Albumin. SN38 is the active metabolite of the prodrug irinotecan, commonly used in ...
Introduction Chemotherapy with anti-tumor agents is currently one of the most important systemic treatments for cancer. However, direct treatment with drugs lacks specificity and sensitivity and tends to attack normal cells indiscriminately, resulting in side effects. ...
Collagen is the main structural protein in vertebrates. It plays an essential role in providing a scaffold for cellular support and thereby affecting cell attachment, migration, proliferation, differentiation, and survival. Natural animal collagen and its recombinant collagen are favorable replacements in human tissue engineering due to their remarkable biomedical property. However, this ...
Especially in terms of dosage, since its therapeutic effect can reach 100-1000 times that of ordinary antibodies, the dosage can be as low as 1/2000 of the original, significantly reducing the cost of drug treatment. Relative to combination therapy, the cost of bispecific antibodies is also much lower than that of two single-agent combination ...
Studies into the degradation mechanism of GlueTACs revealed that treatment with Chloroquine/Bafilomycin significantly reduced PD-L1 degradation, whereas MG132 treatment did not, suggesting that the degradation process depends on the endolysosome pathway. ...
This analysis enables us to pinpoint genes that play pivotal roles in phenotypic variation, disease development, or response to treatments. With RNA-seq, we can capture and quantify the abundance of transcripts, revealing the dynamic landscape of gene expression within a cell or tissue. ...
Enzymes, nature's molecular architects, have been at the heart of industrial processes for decades. Today, the dynamic field of Enzyme Engineering and Modification is driving these biocatalysts towards unprecedented capabilities, triggering a wave of transformative applications across diverse sectors. Decoding Enzyme Engineering Enzyme Engineering stands as a cornerstone of modern ...
Minoxidil was first introduced by Upjohn Company of the United States, and was first used as an oral drug for the treatment of refractory hypertension in the 1970s. In later clinical applications, doctors observed hair regrowth and generalized excessive hair in balding patients, which led to the development of minoxidil preparations. Minoxidil can increase local blood supply, stimulate the ...
The global age-standardized prevalence of type 1 diabetes is projected to increase by 23.9%, from 0.2% in 2021 to 0.3% in 2050. 3. Diabetes Treatment And Prevention Type 1 diabetes is treated with insulin injections. ...
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular ...
This analysis allows us to pinpoint genes that play crucial roles in phenotypic variation, disease development, or response to treatments. With RNA-seq, we can capture and quantify the abundance of transcripts, providing insights into the dynamic landscape of gene expression within a cell or tissue. ...
Liraglutide and exenatide are both belonging to the class of diabetes products called GLP-1 analogues. The GLP-1 analogues have established themselves in the past years as one of the superior drug classes for treatment of diabetes type II in terms of blood glucose lowering and weight loss. Because of the latter, they are being used more and more also in the treatment of obesity. Until now, both ...
Carfilzomib, a proteasome inhibitor, is indicated for the treatment of patients with multiple myeloma. Multiple myeloma (multiple myeloma, MM) is a malignant tumor originating from the B cell lineage, characterized by the clonal proliferation of malignant plasma cells in the bone marrow microenvironment, causing fractures and bone marrow failure, and is the second most common blood system ...
Current schistosomiasis control strategies are geared toward repeated treatment with praziquantel, a drug discovered in the 1970s. Dependence on the drug therapy approach alone is inadequate in the short term because this strategy has had little impact on the reduction of disease transmission and infection rates continue to be ...