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Expression System For Protein Expression Articles & Analysis: This-Year
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Introduction The BALB/C mouse is a widely used inbred strain in biomedical research, particularly in the fields of immunology, cancer research, and genetics. Among the various tissues studied, the kidney holds significant importance due to its complex structure and multifaceted role in physiological functions. A formalin-fixed paraffin-embedded (FFPE) block of the BALB/C mouse kidney serves as an ...
In the intricate world of cellular biology, proteins are the undisputed workhorses. They are assembled based on a genetic blueprint, but their story doesn't end there. After synthesis, proteins undergo a vast array of chemical modifications known as post-translational modifications (PTMs). These changes act as molecular switches, fine-tuning a protein's function, localization, and stability. ...
This approach allows for the insertion of genes encoding viral proteins into suitable expression systems such as bacteria, yeast, or mammalian cells. Once synthesized, these proteins spontaneously assemble into VLPs, providing a scalable and efficient way to produce vaccines. ...
Through its impact on translation efficiency and mitochondrial function tRNA methylation modification also promotes tumor cell proliferation by controlling cell cycle-related protein expression. Cell cycle progression within cells is a critical biological function whose stoppage and progression rely entirely on cell cycle-related protein ...
Recombinant protein expression is a cornerstone of modern biopharmaceutical development, providing the means to produce proteins with therapeutic potential, enzymes, and antibodies. ...
On the other hand, IHC is focused on identifying specific proteins within a tissue sample using antibodies. By employing various tags or enzyme-linked systems, IHC enables the visualization of protein expression patterns. ...
Immunohistochemistry: Frozen sections enable the study of protein expression within lung tissues. Specific antibodies can be used to target and visualize proteins associated with inflammatory responses, fibrosis, and cellular proliferation. Molecular Studies: Techniques such as in situ hybridization can be performed on frozen sections to ...
In the rapidly evolving field of cellular biology and genetic engineering, the development of efficient and reliable cell lines is vital for research and therapeutic applications. One such advancement is the establishment of the Monkey DLL3 stable cell line using HEK293T cells. This article provides an overview of the significance of this cell line, its applications, and the methodology behind ...