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Hplc Articles & Analysis: Older
33 articles found
Antibody drugs are a kind of drugs that treat diseases through artificially synthesized antibodies, achieving therapeutic purposes by specifically binding with target molecules. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, antibody-drug conjugates, etc. Antibody drugs have shown remarkable therapeutic effects in the ...
Ion chromatography (IC) is an analytical technique used to separate and quantify ionic and polar analytes. IC has become widely accepted by the pharma industry and regulatory bodies for an expanded range of applications like water quality and chemical analysis. It has qualified in recent years to analyze pharmaceuticals. The United States Pharmacopeia-National Formulary (USP-NF, US Pharmacopeia ...
ByB&W Tek
Recombinant protein vaccines are vaccines produced using genetic engineering technology. The principle is to clone one or several antigen genes of a pathogen into host cells, causing them to express the corresponding antigen protein. These proteins are then extracted for use in the vaccine. These vaccines can effectively stimulate the immune system to respond to specific pathogens, thereby ...
Collagen is a crucial structural protein, widely presenting in human skin, bones, tendons, ligaments, and other tissues. It's essential for maintaining the structural integrity and function of tissues. The measurement of collagen can help researchers and physicians understand the pathological process of related diseases (such as osteoporosis, arthritis, skin aging etc.), and also aid in drug ...
Collagen is an important structural protein that is widely found in various biological tissues, such as skin, bones, tendons, and blood vessels. Accurate determination of collagen content is very important for biomedical research, disease diagnosis and quality control of related products. Here are some commonly used methods for determining collagen content.ChromatographyHigh-performance liquid ...
Collagen is the most abundant protein in tissues and organs, and glycated collagen refers to collagen modified by glycosylation. Glycated collagen mainly exists in various tissues in the human body, especially those rich in collagen, such as skin, bones, joints, blood vessels, and other connective tissues.Under normal physiological conditions, glycation occurs as a natural biochemical process, ...
Glycosylation impurities are a type of chemical commonly encountered in biochemical, medical, and pharmaceutical chemistry research. The presence of these impurities can affect the efficacy, safety, and stability of drugs. Therefore, the detection and analysis of glycosylation impurities are crucial in ensuring the quality and therapeutic effectiveness of pharmaceutical products.What are ...
Antibody-drug conjugates (ADCs) represent a groundbreaking class of therapeutics that combine the specificity of monoclonal antibodies (mAbs) with the potent cytotoxic effects of small-molecule drugs. This synergistic approach allows for targeted delivery of the cytotoxic agent to cancer cells while sparing healthy tissues, thereby reducing side effects and enhancing therapeutic efficacy. ADC ...
Antibody drug glycosylation analysis is a critical bio-pharmaceutical analysis method, specifically used to evaluate and monitor the glycan structures on antibody drugs. Glycosylation analysis is crucial for ensuring the safety, efficacy, and consistency of drugs, as the structure and composition of glycans directly influence the bioactivity and pharmacokinetic properties of antibody ...
Recombinant protein vaccine is a type of vaccine that does not contain complete pathogens and is prepared from specific protein antigens produced by heterologous expression systems. Due to their advantages of good safety, strong stability, and relatively low cost, recombinant protein vaccines have been widely favored by researchers in recent years. Currently, recombinant protein vaccines have ...
Natural product extraction is a crucial process in the fields of chemistry, biology, and pharmaceuticals. It involves isolating bioactive compounds from plants, animals, and other natural sources to study their properties and potential applications in various industries. There are several methods used for natural product extraction, each with its advantages and limitations. One of the most ...
Collagen peptides are a type of small molecule peptide obtained from collagen through enzymatic hydrolysis or other methods. They typically possess a lower molecular weight, which is beneficial for human absorption. The average molecular weight of collagen peptides usually falls within the range of 1000 to 5000 daltons (Da), although this range can vary depending on the production process and the ...
Collagen is an important protein that is widely present in various human tissues, such as skin, bones, muscle tendons, and ligaments. Accurate determination of its concentration is crucial for multiple fields such as biomaterial research, food industry, and pharmaceutical research.Liquid Chromatography (LC) is an efficient and precise analytical technique for collagen concentration measurement, ...
Recombinant collagen is a type of collagen protein expressed in microorganisms, animal cells, or plants through genetic engineering technology. Compared with collagen extracted from natural sources, recombinant collagen has better safety, purity, and controllability, thus it is widely used in the biomedical and cosmetics industries. The molecular weight of recombinant collagen is an important ...
Testing the content of collagen often involves biochemical analytical methods, which can be either direct or indirect. Here are several common techniques for testing collagen content:1. Hydroxyproline Content Determination(1) Collagen is rich in hydroxyproline, thus, the collagen content can be indirectly calculated by determining the hydroxyproline content of a sample.(2) This method typically ...
Despite the abundant content of collagen, accounting for about 30% of total body protein, it may be difficult to purify and analyze. This is due to collagen molecules forming an extensive network through different types of cross-linking, making the collagen molecules insoluble and difficult to extract.At present, several types of analysis methods are available for collagen analysis:ELISA of ...
Representing the expression, post-translational modification, and protein-protein interaction for certain cells, tissues, or organs, proteomics has become an increasingly important means to understand the molecular mechanism and signal transduction of human disease and cancer. Protein levels in the body are in a steady state of equilibrium. Accumulation of proteins usually leads to qualitative ...
PAI has access to a complete chemistry laboratory facility through a service agreement with the Infectious Disease Research Institute located in the same building. In addition to fume hoods, rotary evaporators, and glassware, we are able to use major equipment including a Bruker Avance 300 MHz NMR spectrometer, Agilent 1100 LCMS, preparative HPLC systems, automatic flash chromatography system, ...
Quality control of hair, skin, and dentalcare products continues to increase in importance for producers. Aside from safeguarding our health, it is equally important to avoid the sale of out-of-specification products. Product recalls are very expensive and have a lasting effect on a company’s reputation. Therefore, intensive testing of these different care products is essential before ...
Pharmaceutical excipients refer to the substances used in the production and formulation of medicines. They perform multiple functions in pharmaceutical preparations and are likely to affect the quality, safety and effectiveness of drugs. Pharmaceutical excipients can be classified into natural, semi-synthetic and fully synthetic compounds according to their sources. And based on their use, ...