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Imaging Microscopy Articles & Analysis: Older
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However, her team's search for new treatments for acute myeloid leukemia was hampered by a subtle gap between two techniques used to understand protein structure and function—X-ray crystallography on the one hand, and cryo-electron microscopy (cryo-EM) on the other. Researchers from Stanford University School of Medicine and Engineering and the SLAC National Accelerator ...
Pathologists conduct a biopsy on a tissue when a carcinoma case for a patient is suspected. They stain the cells on that tissue using some biochemical materials that react with a certain cell element. They put stained cells onto a slide and examine the cells by using an optical microscope device. In our case, we will focus on H&E stained breast tissue samples. Pathologists keep track of a ...
Fluorescence in situ hybridization (FISH) approach is constituted of a pair of complementary techniques for precisely detecting gene amplification and over-expression which are regarded as signs of cancer in patients. Signal detection of FISH whole slides is extremely significant as enables to detect amplification situation. However, nuclei detection and segmentation of FISH slides through ...
An adult human brain contains approximately 86 billion neurons, along with about 85 billion non-neuronal cells. All those cells work together to manage motor control, sensory perception, heart rate, breathing, and more. While the human brain is extremely complex, with the ability to process language, it is not totally unique. Most vertebrate brains are quite similar; they all need similar ...
Nanotechnology has entered the field of medicine in recent dacades and especially, in drug delivery systems, nanoparticles have shown an ability to improve pharmacokinetics, pharmacodynamics, efficacy and to reduce the toxicity of associated drugs. In this study, we have designed a new protoporphyrin-conjugated gold nanoparticle to selectively target and photo- or sonodynamic therapy of tumoural ...
The principle of operation of this technology is to integrate the functions of microscopy, digital imaging, fluidics and image analysis to automatically enumerate and characterize (in terms of size, shape and transparency) particulate matter in liquid samples. MFI™ is such a flow microscopy technique, and operates by ...