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Immunosuppression Articles & Analysis: Older
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The FDA's Center for Drug Evaluation and Research (CDER) regulatory approval of a total of 26 NME (New Molecular Entity) drugs in the first half of 2023. It is worth noting that the 26 drugs approved include 4 peptide drugs, accounting for 15% of the total. In the past 2022, the FDA has approved only three peptide drugs: Tirzepatide, Lutetium 177Lu Vipivotide Tetraxetan and Terlipressin, of which ...
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
What is "click chemistry"? "Click Chemistry", this is a literary name given to this kind of reaction by the Nobel Prize winner K.Burry Sharless, when the cards are put together, "click" (click). Simply put, it is to add two structures to two molecules respectively, and these two structures can be specifically combined to synthesize the required chemical molecules. One of the most famous ...
Ocean Biomedical will be a wholly owned subsidiary of Aesther Healthcare Acquisition Corp. and will change its name to Ocean Biomedical, Inc., expected to be listed on NASDAQ under the symbol, “OCEA”. PROVIDENCE, R.I. and NEW YORK, Sept. 06, 2022 (GLOBE NEWSWIRE) -- Ocean Biomedical and Aesther Healthcare Acquisition Corp. (“Aesther”) (NASDAQ: AEHA) ...
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. In particular, CAR-T therapy, which has been approved by the FDA, is rewriting the treatment paradigm of some hematological tumors. However, adoptive T cell therapy remains of little success in solid tumors. The main reason is that ...
Celdara Medical, LLC today announced that the National Cancer Institute of the National Institutes of Health (NIH) has awarded a Small Business Innovation Research (SBIR) Phase I award to fund the company’s proof of concept studies on a new platform to improve chimeric antigen receptor (CAR) T cells efficacy to treat solid tumors. Dr. Joana Murad-Mabaera, who leads this effort, stated, ...
Strongyloides is an opportunistic pathogenic parasitic nematode. Adults parasitize in the small intestine of cats, dogs and humans. The larvae can invade lung, brain, liver, kidney and other tissues and organs, causing strongyloidiasis. The disease is mainly prevalent in warm and humid tropical and subtropical regions. In recent years, due to the continuous increase of HIV/AIDS infection rate in ...
At present, chimeric antigen receptor T cell therapy (CAR-T) has made significant achievements in the treatment of specific hematological cancers, allowing patients with relapsed/refractory disease to survive longer and become healthier, but in clinical studies, cell therapy has actually not been successful in the treatment of patients with solid tumors, in part due to the lack of tumor targets ...
Background Tumor immunotherapies compose immune checkpoint inhibitors, therapeutic antibodies, tumor vaccines, cellular therapies, and so on. However, each has its own set of issues, such as the fact that CAR-T therapy is an individual therapy that is costly; immune checkpoint inhibitors are highly effective, but only in some patients. The researchers expose us to a radically different way of ...
Glycosylation is a sophisticated type of post-translational modification that impacts over 50% of cellular proteins and is a critical regulator of many eukaryotic processes. Aberrant glycosylation is a common hallmark of many malignancies and is important at all stages of tumor growth. Glycosylation regulates a range of physiopathological processes, including cell-cell adhesion, cell-matrix ...
Pancreatic cancer is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat, and the morbidity and mortality rates have risen dramatically in recent years. Pancreatic cancer is at an advanced stage when diagnosed when cancer cells have spread and are hard to control. The most frequent pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), accounting for ...
Immunotherapy, in addition to surgery, chemotherapy, and radiotherapy, has now become the fourth pillar of anticancer treatment, with T cell-based immunotherapy being a successful cancer treatment technique. T cells can be separated into two subpopulations based on the expression of T-cell receptors (TCRs). αβ T cells, expressing expressing αβ TCR, recognize peptide antigens, such as those ...
Abstract Purpose: The purpose of this study was to describe a novel device that may serve as an alternative to Descemet membrane endothelial keratoplasty (DMEK) for the treatment of chronic corneal edema. Methods: The EndoArt (EyeYon Medical, Israel) is a flexible, 50-μm thin artificial endothelial layer that matches the cornea’s posterior curvature and functions as a fluid barrier ...
Poland has 38 large regional hospitals responsible for hematology and oncology. Genano has delivered a total of over 150 air purifiers to these hospitals. Of the 16 regions in Poland, 13 are using Genano to protect immunocompromised patients. Challenge Polish regional hospitals have recognized the need for protecting patients from infections by providing ultra pure air in patient ...
Blueberry Therapeutics is a drug development company committed to finding new and improved treatments for a range of dermatological conditions affecting the skin and nails. The future and long-term effect of the global COVID-19 pandemic (caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2 virus]) on dermatology practice and skin health is still unknown, but here we provide some ...
The Engineered Micro Pancreas from Betalin Therapeutics is heading closer to clinical trials in humans. Ahead of International Diabetes Day, November 14, Israeli startup Betalin Therapeutics announced that it is beginning the application process for clinical trials of its revolutionary artificial pancreas. Betalin’s Engineered Micro Pancreas (EMP) aims to free patients suffering from the ...
The conversation around diabetes reversal has increased, and when researching diabetes there are numerous states to this claim, but how realistic is it? Sadly, diabetes affects a huge number of people worldwide and is responsible for blindness, kidney disease, limb amputation and death. WHO estimates that diabetes was the seventh leading cause of death in 2016[1] and 422 million adults currently ...
A team of Jerusalem-based researchers and entrepreneurs claim they have a cure for diabetesthat could hit the market as early as within the next few years. Betalin Therapeutics has developed the first bio-artificial pancreas, composed of pig’s lung tissue and insulin secreting cells. The artificial pancreas would be implanted into the patient and connect with his or her blood vessels, ...
Why do we need new cell contenders in the CAR field? Well, different CAR immune cells have different advantages and sometimes unique challenges or limitations. So, we began our discussion of alternative CAR-cell types with CAR-NK cells due to their current standing as the most popular alternative CAR-based therapy. However, the expansion of CARs to other cell types has already begun and ...
Previous studies have shown inexplicable declines in breeding waterbirds within western New York/New Jersey Harbor between 1996 and 2002 and elevated polychlorinated dibenzo‐p‐dioxins and polychlorinated biphenyls (PCBs) in double‐crested cormorant (Phalacrocorax auritus) eggs. The present study assessed associations between immune function, prefledgling survival, and selected organ chlorine ...