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Immunosuppression Articles & Analysis: This-Year
3 articles found
Iptacopan shuts down the alternative pathway specifically, cutting inflammation without broad immunosuppression. It's oral, which is a huge win for daily life. The Proof: Phase III trials (like APPLAUSE-IgAN) showed big drops in proteinuria and better biomarkers, especially if your IgAN is complement-driven. ...
Research efforts now focus on designing next-generation inhibitors with improved selectivity, tissue penetration, and minimal immunosuppressive effects. In parallel, gene-editing strategies and siRNA therapeutics targeting mutant ELANE alleles are being explored for hereditary neutropenia syndromes. ...
The IP10-loaded platelets targeted and inhibited tumor cells in the B16F10 melanoma model and lessened immunosuppressive regulatory T cell activity through CD40L activation on platelet membranes which led to boosted anti-tumor immunity. ...