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In Vivo Study Articles & Analysis: Older
27 articles found
Pharmacokinetics (PK) and pharmacodynamics (PD) are two fundamental pillars in the field of pharmacology and drug development. Understanding their intricate interplay is essential for determining the efficacy and safety of therapeutic compounds. When studied in living organisms, this relationship is referred to as in vivo PK/PD, a discipline that provides invaluable insights into drug behavior ...
The world of drug development has long been marked by the rigorous assessment of cardiac safety. Recognizing the need for a more accurate and efficient evaluation system, the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative emerged. At the heart of this initiative are CiPA Translational Assays, designed to improve the prediction of drug-induced cardiac arrhythmias. Understanding the ...
In vitro permeability assay kits play a crucial role in the field of pharmaceutical development, particularly when evaluating the absorption characteristics of drugs. These kits allow scientists and researchers to investigate how compounds permeate biological membranes, which is vital for understanding drug bioavailability. Understanding Permeability Permeability refers to the ability of a ...
Cell cultures have played a significant role in the academy and pharmaceutical industry, but conventional 2D cultures fail to provide physiological relevance and communication network as compared to in vivo conditions, since they are unable to mimic the complexity of cellular microenvironment, an essential part for the cell behavior and systematic investigation. Using 2D cell culture systems can ...
Introduction In the ever-evolving landscape of drug delivery systems, nanoformulation stands out as a revolutionary approach. Nanoformulation leverages nanotechnology to create drug delivery systems that can improve the efficacy, reduce side effects, and precisely target disease sites. This cutting-edge technology has garnered significant attention from researchers and pharmaceutical companies ...
Introduction For years, scientists have leveraged the brilliant potentialities of genetic science to explore how cells function and interact in living organisms. Among the numerous tools employed are "reporter systems," which use a visible marker to track gene expression, protein interactions, and other vital biological processes. One such system employs reporter lentiviral particles, using the ...
Harnessing the power of cell biology, scientists across the globe are perpetually invested in the pursuit of understanding the complexities of cellular mechanisms and their adaptability. One such venture is the creation of Inducible Expression Stable Cell Line (IESCL) development. IESCL signifies a consolidated methodology designed to explore the potentialities of modulated gene expression. This ...
Rational Vaccines said findings from a pilot study showed that RVX201 led to a reduction in recurrent genital lesions when compared to gD2-alum/MPL vaccine in animal studies. Rational's Experimental Herpes Vaccine Shows Preclinical Promise Rational Vaccines said findings from a pilot study showed that RVX201 led to a reduction in recurrent genital lesions when compared to gD2-alum/MPL vaccine ...
It was great to be back in person at the 2022 BIO International Convention this year. It came as no surprise to us at Recursion that artificial intelligence (AI) and machine learning (ML) were hot topics at the conference, with more than half a dozen sessions exploring how these technologies are driving digital transformation in biopharma. We heard from leaders who are applying AI at ...
Researchers at Massachusetts General Hospital (MGH) have found that interferon gamma receptor (IFNgR) signaling is essential for the susceptibility of CAR-T cell immunotherapy to kill malignant gliomas. The same phenomenon has been observed in other solid tumors. The findings may partially explain why liquid and solid tumors respond very differently to CAR-T cell therapy. Chimeric antigen ...
What is diabetic neuropathy? The most common complication of diabetes is neuropathy, which is nerve damagecaused by high blood sugar. Most neuropathy affects the legs, hands and feet and usually presents as numbness, pain or tingling. Diabetic neuropathy can also seriously impact the heart, blood vessels, digestive system and the kidneys. Symptoms can range from mild discomfort to extreme pain. ...
Summary: Non-union of bone fractures can cause pain and disabilities. Amongst certain fracture types, in specific age groups, the incidence of non-union is over 8% in the United States and over 3.6% of all fractures in the UK. Fracture non-unions have lifelong consequences and a debilitating impact in patients' life. Bone-grafts, allografts and xenograft are currently used to treat bone ...
Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalcitonin superfamily that plays a dual role in prostaglandin metabolism and lipid transport. PTGDS is involved in various cellular processes including solid tumorigenesis, but its role in tumorigenesis is paradoxical, and the significance of PTGDS in hematologic malignancies is not clear. The aim of this new study was to ...
At Recursion, we are working to decode biology and industrialize drug discovery. We have successfully executed over 82 million phenomic experiments and inferred over 179 billion biological relationships in our quest to identify promising novel therapeutic approaches. Now, we are extending our industrialized approach to petabytes of pre-clinical in vivo studies. Digitalizing in vivo studies ...
Both current in vitro and in vivo models used in the development of candidate therapies for the treatment of intestinal diseases have severe limitations. RepliGut®, an in vitro human intestinal epithelial stem cell model, addresses many of these issues and has significant potential to reduce the time and cost of drug development. This model may even help to identify optimal therapies for ...
Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone, time and cost intensive and lack reproducibility in clinical settings. The paper demonstrates how a computational platform integrating ...
Advanced microphysiological systems can replicate aspects of intestinal complexity, such as epithelium self-renewal by stem cells in in vitro crypts or the interactions of microbes and intestinal epithelium mediated by a mucus layer. Availability of such models is key to progress in compound screening, disease modeling, and microbiome research. Defining a Niche A niche is a multidimensional ...
Due to a lack of robust in vivo gut models, animal studies are generally required to evaluate gut toxicity. However, these studies can be lengthy and expensive and may not accurately recapitulate the behavior of the human gastrointestinal tract. Drugs are thus often developed with undesired gut side effects that are not apparent until clinical trials. Organ-on-a-chip models are the closest ...
The Five Factors Research organizations are under pressure to cut costs while maintaining or increasing throughput. To improve their operations, many laboratories are considering investments in data management or support and automation systems like ELNs, LIMS or Robotics/HTS. Whatever the change that is introduced, there are many pitfalls on the way to delivery, roll-out and successful ...
Endocrine disrupting compounds (EDCs) can impact the reproductive system by interfering with the hypothalamic‐pituitary‐gonadal (HPG) axis. While in vitro testing methods have been developed to screen chemicals for endocrine disruption, extrapolation of in vitro response to in vivo action shows inconsistent accuracy. We describe here our tissue co‐culture of the fathead minnow (Pimephales ...