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Inflammation Chronic Articles & Analysis: Older
13 articles found
Skeletal muscle microvascular endothelial cells (SMECs) play an essential role in maintaining muscle function, metabolism, and overall health. These specialized cells line the blood vessels within skeletal muscles, forming a barrier that regulates the exchange of substances between the bloodstream and muscle tissue. Their significance extends beyond mere structural support; they actively ...
The Triggering receptor expressed on myeloid cells 1 (TREM1) protein has emerged as a pivotal player in the intricate web of immunological responses, particularly in the context of inflammatory diseases. Unraveling the mysteries of TREM1 entails delving into its structure, function, and implications in various pathological conditions, shedding light on its potential as a therapeutic target. ...
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. We recently reported that many RA patients have anti-citrullinated albumin (ACA) ...
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune ...
Introduction to IL-36 Family Twenty years ago, Interleukin 36 (IL-36) was discovered as a member of the IL-1 superfamily. Its gene is located on chromosome 2 in an IL gene cluster, including IL1A - IL1B - IL37 - IL36G - IL36A - IL36B - IL36RN - IL38 - IL1RN, with IL-36 encoding genes transcribed far away from the centromere. There are four known subtypes of IL-36, which have been renamed multiple ...
Heart failure affects about 6.2 million Americans and is rising in prevalence. With half of these cases presenting as heart failure with preserved ejection fraction (HFpEF), it’s essential for both the medical community and the population at large to have a better understanding of its pathology. [1,2] Knowing the differences between HFpEF and its counterpart, heart failure with reduced ...
Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nano-size particles to small chemical compounds to large fragments of DNA. As a versatile peptide, CPP has been widely used for diagnostic and therapeutic applications. 1. Oligo and siRNA Transport As an important means for targeted therapy of specific genes, oligonucleotides ...
By not taking care of your teeth there is more on the line than tooth decay and periodontal disease – although that’s bad enough. Practicing good oral hygiene may be lifesaving according to a number of research studies.Studies show a connection between Gum disease and a 63% HIgher Pancreatic Cancer in Men The link between several systemic illnesses including diabetes, heart disease, ...
Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. We ...
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. TNF-a activation of ...
In a new study, researchers from the National Institute of Dental Craniofacial Research (NIDCR) have found that blocking the function of a coagulation protein prevents bone loss caused by periodontal (gingival) disease in mice. According to animal and human data, they found that the accumulation of this clotting protein called fibrin triggers an excessive immune response that damages the gingiva ...
ByMatexcel
If you or your child suffers from asthma, you’ve probably heard the term, “pediatric asthma”. However, understanding exactly what pediatric asthma is and how it affects your child is critical in managing their asthma. Furthermore, you may be wondering, does pediatric asthma only apply to children? Perhaps you’re even wondering if your child will outgrow pediatric ...
ByAluna
Upset stomach, heartburn, diarrhea? There are few symptoms as disruptive to your daily life as ones that originate in the digestive system. And if you’re struggling with any of these symptoms, you know exactly how difficult they are to get rid of for good. Doctors recommend a variety of treatments, but there are three biggies they suggest most often for patients who are dealing with both ...