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Laboratory Homogenizer Articles & Analysis: Older
42 articles found
For example, you might want to know if the concentration of a certain nutrient (factor) affects the growth rate (outcome) of a specific type of bacteria in a laboratory setting. Step 2: Identify the levels and groups The next step is to identify the levels and groups of your factor(s). ...
In recent years, the landscape of sequencing technologies has undergone a transformative shift, transitioning from research settings to the realm of clinical laboratories. This transformation has been catalyzed by rapid technological advancements and significant cost reductions. ...
The immune system plays a crucial role in protecting the body from harmful pathogens and foreign invaders. Immune receptors, which are protein molecules expressed on the membrane of immune cells, play a key role in regulating immune responses. These receptors can interact with specific ligands to trigger a cascade of events that lead to the activation or suppression of immune responses. Immune ...
Vaccines have been essential in disease prevention, and the requirements for vaccine quality continue to increase. The application of advanced separation and purification technologies during the preparation of traditional and new vaccines is an effective means to improve vaccine efficacy and reduce side effects. Here are some commonly used purification methods: Centrifugal 1. ...
Antibody-drug conjugates (ADCs) represent a groundbreaking class of therapeutics that combine the specificity of monoclonal antibodies (mAbs) with the potent cytotoxic effects of small-molecule drugs. This synergistic approach allows for targeted delivery of the cytotoxic agent to cancer cells while sparing healthy tissues, thereby reducing side effects and enhancing therapeutic efficacy. ADC ...
Autophagy is a highly conserved catabolic process in which long-lived cytoplasmic components or damaged organelles are sequestered by the formation of double-membraned autophagosomes. Mature autophagosomes ultimately fuse with lysosomes to form single-membraned autophagolysosomes that degrade or recycle their contents. Upon autophagy initiation, microtubule-associated protein 1 light chain 3 ...
Vaccines have been essential in disease prevention, and the requirements for vaccine quality continue to increase. The application of advanced separation and purification technologies during the preparation of traditional and new vaccines is an effective means to improve vaccine efficacy and reduce side effects. Here are some commonly used purification methods: Centrifugal 1. ...
Poly(lactic-co-glycolic acid) (PLGA) is a functional polymer organic compound randomly polymerized by lactic acid (PLA) and glycolic acid (PGA). It has been approved by the U.S. Food and Drug Administration It is certified by the Food and Drug Administration (FDA) and is a copolymer material available on the market. PLGA has good biocompatibility, biodegradability, mechanical strength, good ...
Protein fusion is a genetic recombination technique in which the DNA of an inactive peptide or protein chain segment to be grafted is recombined with the DNA of a drug and expressed together by engineered cells; no specialized grafting operations are required. In the current technology, the inactive peptide or protein chain segment used for protein fusion is the FC region of albumin and antibody. ...
Bioproduction is a critical element in the creation of many vaccines, therapeutics, and other biopharmaceuticals. A central facet of this process involves the development of stable cell lines that are capable of producing these vital products in abundance and with consistency. This article will explore the in-depth process and importance of stable cell line development in bioproduction. The ...
Nano-vesicles, also known as liposomes, have emerged as promising drug delivery systems due to their unique structure and properties. These tiny spherical lipid bilayers can encapsulate various therapeutic agents, including protein drugs. In this article, we will explore the process of preparing nano-vesicles for encapsulating protein drugs, as well as the advantages of utilizing this innovative ...
Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them. ADC is a monoclonal antibody covalently bound to cytotoxic chemical substances (payload) through linker. ADC linker plays a key role in the therapeutic effect of ADC, and its characteristics greatly affect the therapeutic index, pharmacodynamics and ...
In the past ten years, the number of antibody drug conjugates (ADCs) entering clinical trials has steadily increased. Currently, 9 ADCs have been approved, of which 5 are used for hematoma and 4 for solid tumor treatment. After more than 20 years of development, ADC biopharmaceuticals are becoming the main force in the treatment of cancer. Currently, one of the most important challenges when ...
Structurally, an ADC consists of monoclonal antibodies (Antibody) that target specific antigens on tumor surfaces, cytotoxic drugs (drugs) that kill tumor cells, and linkers (Conjugate/ linkers) that conjugate cytotoxic drugs to antibodies. The link between the antibody and linker is controlled by the coupling method, which determines the DAR value of the drug and affects the stability and PK ...
Drug-to-antibody ratio (DAR, drug-to-antibody ratio) The number of cytotoxic drugs connected to each antibody is the drug-to-antibody ratio (DAR). When the DAR increases, the drug metabolism rate of ADC drugs increases, the half-life decreases, and the systemic toxicity increases. Ideally, when the DAR is 4, the drug has the highest efficacy. Therefore, in actual production, the drugs with DAR ...
In today’s healthcare environment, the general consensus is that the exchange and flow of data is crucial and beneficial to developing better care of the patients. Healthcare information exchanges (HIEs), as an example, have shown to be effective in improving public health, reducing healthcare redundancies, and providing clinical providers with more support tools in their day-to-day work. ...
This case study illustrates designing and fabricating silicone bolus using the Adaptiiv software solution. This flexible silicone bolus fabrication process was then compared to the fabrication process of a rigid 3D printed bolus to determine whether it yielded comparable or improved plan metrics for treating an inner canthus ...
The cell is the basic unit of life. Most current studies on the human genome, cancer or other fields are still conducted from the population level, and the results are often the mean value of gene expression in cell populations or only represent information on the vital activities of numerically dominant cells, while failing to accurately reflect much of the information on cellular heterogeneity ...
Infants with gas trapping are difficult to manage with conventional ventilation (CMV). HFJV has been used successfully in infants with severe gas trapping. The techniques used during HFJV in this situation are often described as a "low volume strategy". However, there is little published data to indicate optimal ventilator settings, both Jet and conventional, to achieve these aims. During HFJV ...
Antibody-drug conjugate (ADC), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic agent into the tumor, has made significant progress in the previous decade. The first ADC drug approved by the US FDA was gemtuzumab ozogamicin (Mylotarg) in 2009. Currently, the FDA has authorized ...