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Lung Tissue Articles & Analysis: Older
21 articles found
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. ...
The effectiveness of ELANE as an antimicrobial enzyme is supported by in vivo studies showing increased susceptibility to bacterial infections in ELANE-deficient models. Dysregulation and Tissue Damage: The Inflammatory Trade-off While ELANE is crucial for defense, its unregulated activity is a major contributor to inflammatory tissue injury. The enzyme can ...
Research in the field of pulmonary biology often requires detailed analysis of lung tissues. One of the optimal methods for studying lung structures and functions in mice is the use of C57 mouse models, specifically through the preparation of frozen sections. ...
Sleep apnea is a sleep disorder that is characterized with snoring and frequent interruptions in breathing, when asleep. That impacts quality sleep and puts the individual at risk of health issues. Though CPAP therapy is considered gold standard in treating sleep apnea, there are a multitude of vitamins and minerals that can help you get better sleep by addressing factors like muscle relaxation ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
This enzyme is known for its ability to degrade elastin, a key protein that provides elasticity and resilience to tissues such as skin, lungs, and blood vessels. Understanding the functions and implications of elastase is crucial in biochemistry and medicine, as it has a significant impact on both health and disease. ...
They are present in most connective tissues. MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, and MT1-MMP and MT3-MMP are expressed in various vascular tissues and cells. ...
We compared the differential gene expression in non-small cell lung cancer (NSCLC) between two platforms in order to find the most relevant genomic signatures of tumor recurrence. Materials and Methods We analyzed gene expression in frozen lung cancer tissue from 59 selected patients who had undergone surgical resection of NSCLC. ...
This DDS also prevents topical stimulation of lung tissue and reduces drug toxicity. Using surface-bound ligands or antibodies, the most significant advantage of liposome formulations for pulmonary administration application is the targeting of specific cell populations.Enhance antibiotic efficacy and safetyMany factors hinder the effective therapeutic effects of ...
Adults parasitize in the small intestine of cats, dogs and humans. The larvae can invade lung, brain, liver, kidney and other tissues and organs, causing strongyloidiasis. ...
” But researchers are making steady progress in developing strategies that can help to shepherd these drugs to specific organ systems while sparing other, non-target tissues. Adeno-associated viruses are the vehicle of choice for many gene-therapy efforts, and animal studies have shown that careful selection of the right virus combined with tissue-specific ...
When natural respiratory humidification decreases pulmonic infections and damage to lung tissue may ...
As an example, breathing is a key functional endpoint in patients with lung fibrosis. As the severity of fibrosis increases, elastic and functional tissue in the lungs is replaced with inelastic scar tissue, which makes breathing a challenge. ...
In around 50% of people living with SLE, a major organ or tissue, such as heart, lungs, kidneys or brain, will be affected. Recent clinical developments in SLE, and the associated lupus nephritis, have focused on inhibiting the activation of auto-reactive B-cells or pathways leading to autoimmunity and inflammation. ...
“They need to be surrounded by some sort of supporting tissue – a scaffold, we call it,” Betalin CEO Nikolai Kunicher tells ISRAEL21c. ...
Betalin Therapeutics has developed the first bio-artificial pancreas, composed of pig’s lung tissue and insulin secreting cells. The artificial pancreas would be implanted into the patient and connect with his or her blood vessels, and then be able to measure the body’s sugar level and secrete an optimal amount of insulin needed to balance blood ...
However, ENDS exposure, independent of nicotine, altered lung lipid homeostasis in alveolar macrophages and epithelial cells. ...
We confirmed that 0.5 Gy whole-body gamma-ray irradiation (four doses over two weeks) significantly suppressed colony formation in the lungs. In the lung tissue 24 h after irradiation, both the level of matrix metalloproteinase-2 (MMP-2) protein and its activity were significantly decreased. We also found that the activity of MMP-9 was ...
The phantom was constructed in-house by tissue substitutes representing bone skeleton, muscular tissue, lungs, mediastinum and the organs of the upper quadrants of the abdomen, such as the liver and spleen. A tomography was accomplished showing the radiological response verifying the similarity of the electronic density obtained by the number of ...
ICRP Publication 66 that had adopted a new approach to estimate dose to lungs and an extrathoracic region based on a revised human respiratory tract model was considered by the authors to address some aspects related to application of ICRP 66 in radiation safety practices. Comparison of committed equivalent doses received to the lungs following acute inhalation ...