Metabolic Stress Articles & Analysis: Older
11 articles found
At its core, Lipid Metabolism encompasses the intricate biochemical processes involved in the synthesis, breakdown, and transport of fatty acids, cholesterol, and other lipid molecules. ...
Investigations into the mechanisms of podocyte injury are ongoing, with a focus on understanding how factors like inflammation, oxidative stress, and metabolic changes contribute to podocyte damage. By elucidating these pathways, researchers hope to identify potential therapeutic targets to prevent or reverse kidney damage. ...
NAD and NADH are not merely passive participants in metabolism—they are regulatory molecules that influence key metabolic pathways, including glycolysis, oxidative phosphorylation, and biosynthetic reactions. ...
This method is particularly valuable for identifying the target genes regulated by microRNAs (miRNAs), which are small, endogenous non-coding RNAs approximately 22 nucleotides in length. miRNAs play crucial roles in various biological processes, including cell proliferation, apoptosis, differentiation, metabolism, and responses to environmental stresses such as ...
While many factors like activity levels or stress can impact metabolic rate, it scales consistently with body size and environmental temperature. ...
Advanced glycation end products (AGEs) have been demonstrated in studies to cause inflammation and oxidative stress in various tissues, resulting in a positive feedback loop that increases AGEs. ...
Type 2 Most typically linked to old age, a family history of the disease or being overweight, type 2 diabetes occurs due to fatty accumulation in the liver (limiting its responsiveness to insulin which means that more glucose is then produced) and the pancreas (causing metabolic stress which stops ß cells from functioning). Individuals with type 2 ...
Abstract Class 1 plant hemoglobins (phytoglobins) are upregulated during low-oxygen stress and participate in metabolism and cell signaling via modulation of the levels of nitric oxide (NO). We studied the effects of overexpression and knockdown of the class 1 phytoglobin gene in barley (Hordeum vulgare L.) under low-oxygen stress. The ...
The presence of biologically active substances (BAS) in biosolids may enhance plant stress tolerance and growth, but the underlying mechanisms are not well understood. This greenhouse study investigated the effects of untreated biosolids, containing 2.1 µg indole-3-acetic acid (IAA) g–1, and tryptophan-treated biosolids, containing 15.4 µg IAA g–1, on tall fescue [Lolium arundinaceum (Schreb.) ...
The LuxS enzyme, catalyzing the production of the autoinducer-2 signaling molecule, also forms an integral part of the activated methyl cycle and the metabolism of methionine and cysteine. The genuine luxS mutant CMPG5412 showed drastically reduced persistence in mice, which was related to less survival in simulated gastric juice, indicating that LuxS metabolism ...
Δ6-desaturase is a membrane bound enzyme located in a pivotal position within the Essential Fatty Acid metabolic pathway. Changes in the activity of Δ6-desaturase affect the cellular provision of long chain polyunsaturated fatty acids and therefore factors that influence this enzyme are considered relevant to disease processes. This study investigated the effects of social ...