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Neurodegeneration Disease Articles & Analysis: Older
58 articles found
Neurotrophic factors are a group of proteins that play a crucial role in the growth, survival, and differentiation of neurons in the nervous system. They serve as essential signaling molecules that not only support the development of the nervous system during embryonic stages but also maintain neuronal health throughout an individual’s life. These factors are vital for neuroplasticity, ...
Chemokines are a specialized subset of small cytokines that play a crucial role in the immune system by directing the movement of circulating leukocytes to sites of inflammation, infection, and injury. Acting as chemoattractant molecules, chemokines are central to both innate and adaptive immunity, influencing not only immune surveillance but also wound healing and angiogenesis. Over the past few ...
The advent of organoid technology has transformed biomedical research through the development of 3D models that precisely replicate human organ structures and functions in a physiological context. Creative Bioarray establishes itself as a world leader in life science innovation through its complete range of organoid services that enhance drug discovery, disease modeling, and personalized ...
In the realm of drug discovery, the search for innovative therapies often leads to new paradigms. One such paradigm that has gained significant traction in recent years is the development of PROTAC (Proteolysis Targeting Chimeras) technology. This groundbreaking approach unlocks new potential in targeting previously “undruggable” proteins, paving the way for transformative therapies ...
Human astrocytes-cerebellar (HA-c) represent a significant advancement in the field of neurobiology, particularly in understanding cerebral development, functionality, and pathology. Astrocytes, the star-shaped glial cells in the brain, play crucial roles in maintaining homeostasis, supporting neuronal function, and responding to injury. The cerebellum, responsible for motor control and cognitive ...
Each of these targets the malignancy through different mechanisms, offering multiple ways to tackle the disease. Chemotherapy APIs function by disrupting cell division processes, which inhibits the rapid replication of cancer cells. ...
Cytokines and growth factors are essential signaling molecules that play pivotal roles in immune regulation, inflammation, tissue repair, and numerous physiological and pathological processes. To comprehensively study these molecules, scientists often rely on high-throughput and sensitive technologies, among which Luminex Cytokine Panels have become a gold standard. This article delves into the ...
What Is PROTAC Technology? Proteolytic targeting chimera (PROTAC) is a new type of drug design technology that works by inducing the degradation of target proteins. Unlike conventional small molecules that typically inhibit protein function, PROTACs facilitate the ubiquitination and subsequent degradation of specific proteins. This bifunctional molecule consists of two distinct elements: a ...
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in the regulation of gene expression. Their ability to modulate various biological processes makes them significant players in the field of molecular biology and medicine. Among the various tools utilized in research and therapeutic applications, miRNA mimics have emerged as powerful instruments for manipulating and ...
Human umbilical cord cells, particularly those found in Wharton’s jelly, have emerged as a focal point in regenerative medicine and cellular therapy. Wharton’s jelly is a gelatinous substance that surrounds the umbilical cord’s blood vessels, providing structural support and protection. It is rich in mesenchymal stem cells (MSCs), which are known for their unique regenerative ...
Differentially expressed proteins refer to proteins that show significant changes in their expression levels in different biological samples or under different treatment conditions. Observing such differential expression is crucial for understanding cellular physiology and disease mechanisms. For example, some proteins may be upregulated or downregulated in health and disease states, or between ...
Protein phosphorylation is an important post-translational modification process that involves adding a phosphate group to an amino acid residue in a protein, usually a serine, threonine, or tyrosine residue. Protein phosphorylation plays a key role in regulating various biological processes within the cell, including signal transduction, cell cycle, and metabolism. Therefore, detecting protein ...
Plasma proteomics is an emerging field of science dedicated to the analysis and understanding of the protein composition in the plasma and its functions. Plasma, as one of the most abundant biological fluids in the human body, contains tens of thousands of proteins, reflecting the health status, disease process, and treatment response of the body. Therefore, plasma proteomics holds great ...
Acetylation detection of a specific protein is a method used to determine whether and where acetylation modifications have occurred on a protein. Acetylation is a common post-translational modification of proteins, typically occurring on lysine residues of proteins, and plays a crucial role in regulating protein function, cell signaling, gene expression, and disease onset. For instance, the ...
Oxidative phosphorylation is the process by which mitochondria produce ATP (adenosine triphosphate) in the cellular respiration chain. It is a crucial step in cellular energy metabolism. In this process, electrons are transferred from one carrier to another through a series of oxidation-reduction reactions and are ultimately passed to oxygen to form water. The energy released by this electron ...
In biomedical research, the detection and analysis of biomarkers are crucial. Among them, glycoproteins are an essential biomarker that plays a key role in many biological processes, including disease onset, progression, and treatment response. The Tandem Affinity Purification (TAP) of glycoprotein is an efficient detection method.What Is a Glycoprotein?Firstly, let's understand what a ...
Mitochondria are a unique type of organelle present within cells, serving as the primary source of energy within living organisms. They are responsible for several life-sustaining processes, including energy production, reducing free radicals, and maintaining cellular signaling. Proteins within the mitochondria play a key role in these processes.Why Sequence Mitochondrial Proteins?The sequencing ...
When it comes to the fascinating world of proteins, some names like collagen or hemoglobin might ring a bell. But what about tenascin-C, more commonly known as TNC protein? This often-overlooked molecule plays a vital, if subtle, role in how our cells talk to each other. Let's delve into the remarkable story of TNC protein and why it deserves more of the spotlight. What is TNC Protein? Before ...
Autophagy is an intracellular system that degrades cytosolic proteins and organelles. Autophagy can be divided into three groups: macroautophagy, microautophagy and chaperon-mediated autophagy (CMA). Macroautophagy is most extensively studied and best known among the three pathways. When macroautophagy is induced, an isolation membrane encloses a portion of cytoplasm, forming a characteristic ...
Tau protein is a microtubule-associated protein, mainly present in nerve cells, and participates in the stabilization of microtubules. In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is a kind of post-translational modification of ...