Nmr Articles & Analysis: Older
25 articles found
This technology enables the detailed identification and quantification of lipids and metabolites from small samples like exosomes, which are typically limited in number. NMR spectroscopy is another useful technique in metabolomics, providing structural information on metabolites. ...
Metabolomics services typically involve techniques like mass spectrometry (MS) and nuclear magnetic resonance (NMR) to identify and quantify numerous metabolites simultaneously. This ability is crucial for: Metabolic Pathway Elucidation: Detecting changes in metabolite concentrations reveals clues about the regulation of important pathways, such as the glycolytic pathway or the ...
Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy. Proceedings of the National Academy of Sciences. 2009 Dec 29;106(52). ...
Techniques such as capillary isoelectric focusing (cIEF) and capillary zone electrophoresis (CZE) are frequently utilized. Nuclear Magnetic Resonance (NMR) Spectroscopy NMR spectroscopy plays a critical role in structural elucidation of ADCs. ...
Glycan Structure IdentificationMethods like Mass Spectrometry (MS) or Nuclear Magnetic Resonance (NMR) are used to analyze the structure of the separated glycans.4. Data AnalysisThe obtained data is analyzed to understand how glycans influence the function of the antibody drug.Glycosylation analysis is crucial for ensuring the quality and efficacy of antibody drugs, particularly ...
Hydrogen is the most common target nucleus (1H-NMR), while other atoms such as carbon (13C-NMR) and phosphorus (31P-NMR) can also be used to obtain information on specific metabolite types by NMR techniques. Currently, 1H-NMR spectroscopy, 2H-NMR spectroscopy, and high-resolution magic angle ...
Also Carbon-13 has a non-zero spin quantum number of 1/2, thus permitting the use of Carbon13 NMR to study the structure of carbon-containing materials. In addition, the Carbon-13 Urea Breath Test is a safe and highly accurate diagnostic tool for detecting the presence of Helicobacter pylori infection in the stomach. ...
Structural information can be obtained using X-ray diffraction (for AH adjuvants only), spectroscopy (FTIR, NMR, Raman) and transmission electron microscopy. Granularity Aluminum adjuvants typically consist of primary nanoparticles that form irregularly shaped aggregates ranging in size from 1 to 20 μm. ...
The selection of ADC starting materials is usually discussed with the FDA at the EOP2 meeting.In addition, the payload/linker/payload-linker should be structurally characterized (UV, IR, NMR, mass spectrometry, elemental analysis, etc.) and stability methods indicating purity should be verified to determine the impurity profile. ...
While advanced analytical techniques like mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy provide valuable information about the mass and structure of metabolites, confidently identifying metabolites from complex spectra remains a complex task. ...
NMR exploits the magnetic properties of atomic nuclei to unveil the structural composition of molecules. ...
Typically, the protein structure is determined using techniques such as x-ray crystallography, NMR spectroscopy, cryo-electron microscopy (cryo-EM), or homology modeling. ...
X-ray crystallography, nuclear magnetic resonance (NMR), and surface plasmon resonance (SPR) are commonly used techniques for determining the structures and interactions of protein-DNA complexes. X-ray crystallography requires high-quality crystals and is not suitable for all molecules, whereas NMR can be used to study molecules in solution. SPR is a label-free ...
Quality control Various methods for quality control of polysaccharide vaccines, such as size exclusion chromatography (SEC), high-performance anion-exchange chromatography coupled with pulsed amperometric detection (HPAEC-PAD), and nuclear magnetic resonance ...
We have expertise and experience in protein 3D structure prediction, protein modeling, and data analysis. Related services include: Rheo-NMR service, co-crystallization, membrane protein structure determination by solid-state NMR, stable isotope labeling for nucleic acids, crystallization chaperone strategies, and immunoelectron microscopy service. ...
The success of protein-small molecule docking depends on the accuracy of the protein structure and the small molecule's physiochemical properties. X-ray crystallography and NMR spectroscopy are the most accurate methods of obtaining the protein structure. ...
In addition to fume hoods, rotary evaporators, and glassware, we are able to use major equipment including a Bruker Avance 300 MHz NMR spectrometer, Agilent 1100 LCMS, preparative HPLC systems, automatic flash chromatography system, hydrogenator, and ozone ...
The researchers used 16S rRNA gene targeted sequencing (16S), meta-genomics (MG), meta-transcriptomics (MT), and nuclear magnetic resonance metabolomics (NMR) to comprehensively study dolphin gut bacteria. Studies have found that the taxonomic structure of intestinal bacteria in the cecum and rectum of dolphins is mainly dominated by bacteria, while archaea and fungi account for ...
The relatively small size of KIX, by cryo-EM standards, makes it a challenge. Another option, NMR, has been used to determine the structure of KIX when bound to other naturally-occurring molecules, but the method requires extensive preparation and analysis, making it less suitable for rapidly determining the structure of molecules, and therefore less suitable for studying the ...
Metabolomics is an important omics technology based on high-throughput analysis technology (chromatography-mass spectrometry, NMR) and bioinformatics. It has progressed considerably in the past ten years, and its use has been broadened in various fields of life science and medical research. ...