Platelet Coagulation Articles & Analysis: Older
2 articles found
Ceramide and Cardiovascular Diseases Elevated ceramide concentrations can lead to apoptosis of vascular endothelial cells and regulate platelet activation and coagulation, leading to thrombosis. It also regulates angiotensin, which can lead to atherosclerosis and a number of cardiovascular diseases such as hypertension. ...
Another top-selling covalent drug is clopidogrel, which needs to be activated by P450 oxidase in the liver to produce a sulphur-containing compound that then forms a disulfide bond with a cysteine residue in the P2Y12 receptor to inhibit platelet coagulation. The above-mentioned two drugs are now very widely used and were not originally designed to act in a ...