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Postmortem Articles & Analysis: Older
4 articles found
Abstract Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping2,3,4,5, but the ability to capture spatial epigenetic information of tissue at the cellular level and genome scale is lacking. Here we ...
Although post-mortem brains have been frequently reported as the "gold standard" in transcriptomic research for ND and neuropsychiatric abnormalities, the main sources has been mRNA separated from transgenic animal models and, more lately, patient-derived cell lines. However, despite their promise, transcriptome studies are difficult due to the obvious difficulties in obtaining brain tissue and ...
Abnormal accumulation of misfolded tau in filaments is characteristic of many neurodegenerative diseases—precisely for this reason, these neurodegenerative diseases are collectively referred to as tauopathy. The Michel Goedert team and the Sjors Scheres team at the Molecular Biology Laboratory of the Medical Research Council in Cambridge, UK, witnessed the use of cryo-EM to dissect tau ...
The Ashford and St Peter's NHS Trust in the UK has chosen Matrix Tracker to manage and track the transition of bodies through the hospital mortuary. Organisation Ashford and St. Peter's Hospitals NHS Trust was formed in April 1998 and manages two sites; Ashford Hospital in Middlesex and St. Peter's Hospital in Chertsey, Surrey. The mortuary at Ashford and St Peters Hospital (ASPH) is an ...