Preclinical Data Articles & Analysis: Older
18 articles found
For instance, CXCL10 has shown promise in preclinical models by enhancing T-cell infiltration into tumors. Additionally, chemokines play a role in vaccine development. ...
This technique can evaluate the binding affinity, specificity, and cellular uptake of ADCs, providing essential data for preclinical and clinical studies. Surface Plasmon Resonance (SPR) SPR is a label-free technique used to study the binding interactions between the antibody and its target antigen. By providing real-time data on binding ...
It is only through repeated and varied pre-clinical studies that researchers can ensure that cases retain confidence in the therapy when entering the clinic. In a word, the data collected from preclinical studies are important to provide the necessary validation for non-clinical endowments and to guide the development of new strategies for brain tumor therapy. ...
The study of respiratory function and control of breathing is vital for understanding various physiological and pathological conditions. In preclinical research, gaining accurate and reliable data is essential to make meaningful discoveries and develop potential therapies. ...
Enfortumab vedotin-ejfv (PADCEV®) is a first-in-class antibody-drug conjugate (ADC) that targets Nectin-4, a cell surface protein highly expressed in bladder cancer. Preclinical data suggest that the anticancer activity of Enfortumab Vedotin is attributed to its binding to cells expressing Nectin-4, followed by internalization and release of the anti-tumor ...
According to the latest data, breast cancer has overtaken lung cancer to become the most common cancer among women, and the death rate is the second highest among female tumors, seriously affecting the physical and mental health of women around the world. ...
I did find a lot of data about the effect of drugs in clinical trials (e.g. the effect a drug has on humans), but surprisingly enough, not many of those drugs show up in the preclinical database (where I was hoping to find info on how cell cultures and animals react to the drug). ...
Rational's Experimental Herpes Vaccine Shows Preclinical Promise Rational Vaccines said findings from a pilot study showed that RVX201 led to a reduction in recurrent genital lesions when compared to gD2-alum/MPL vaccine in animal studies. ...
AFM13 is a first-in-class tetravalent, bispecific NK cell engager that binds to CD30 on tumor cells and CD16A on NK cells. By engaging CD16-positive NK cells, AFM13 leads to NK cell-mediated killing of tumor cells.1 Pembrolizumab (Keytruda®) is approved in patients with R/R classical Hodgkin lymphoma as monotherapy. AFM13 showed single agent clinical activity with solid safety profile in a ...
” This translational study analyzed patient tissues, preclinical models and retrospective data to determine how the IL-6 T helper 17-cell (Th17) pathway is involved in toxic responses and can be inhibited to separate inflammatory autoimmune responses and antitumor immunity reaction. ...
December 28, 2021 - Rational Vaccines announced preclinical research suggesting that the Company's herpes simplex virus type 1 (HSV-1) vaccine candidate (RVX1001) can protect against herpetic keratitis, a leading infectious cause of blindness in developed countries. ...
As a result, while performing clinical trials, the limitations of data obtained from preclinical animal model studies must be understood and taken into account. ...
Mir Hashim, SCO of Rani, says the microinjector technology has been assessed in multiple preclinical studies, with canines and pigs, and three endoscopic studies in the small intestine between the duodenum and ileum. Repeat safety studies also have been conducted for daily delivery up to seven days, with no evidence of tissue damage. In its preclinical program, ...
In our work with Progenza™, we are injecting the technology directly into the affected joints as you would with human patients. The resulting data will provide a strong indication of how Progenza™ works in an OA joint. ...
“Overall, with the downstream physiological activation shown, these data have compelling implications for the development of highly immunogenic, T cell-focused global vaccines against various pathogens and diseases. We look forward to leveraging our proprietary data science and therapeutic platform to continue investigating this ...
Even so, the standard paradigm for preclinical ADME data translation includes: (1) testing a compound in preclinical subjects and collect outputs, (2) building 1- or 2-compartment model of compound PK, or use physiologically-based pharmacokinetic models (PBPK), (3) fitting model parameters to the compound PK data, (4) scaling ...
Initially, I was responsible for optimising our product manufacturing processes, including manufacturing products for our preclinical and clinical trials. For example, I provided the data to support preclinical studies that evaluated Progenza™ for osteoarthritis in rabbits and pain in rats. Currently, my focus is on conducting assurance ...
Experience: Find your carrots Biologists in a global pharmaceuticals company were capturing and managing preclinical in vivo data with ad-hoc and Excel-based approaches. They were comfortable with this approach, but this made this critical data hard to find, hard to understand and hard to reuse by the modellers who wanted to introduce better ...