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Therapy Development Articles & Analysis: Older
45 articles found
These cell lines, often derived from human tumors, offer insights into the genetic and molecular underpinnings of cancer, helping researchers develop targeted therapies. Additionally, they are integral to personalized medicine, allowing for the testing of patient-specific treatments. ...
The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. ...
The battle against brain tumors is being revolutionized by biotechnology, leveraging cutting-edge innovations to develop more effective treatments. Overall, the integration of multi-omics data and advancements in immune-oncology plays a significant part in developing precise treatments for brain tumors2. ...
In response to the emerging needs in global healthcare, SOPHiA GENETICS has just revealed the New Generation SOPHiA DDM™ Platform, aiming to stay at the forefront of precision medicine and address today the healthcare needs of tomorrow. ...
Notable examples include PEGylated interferons used in the treatment of hepatitis and PEGylated enzymes for enzyme replacement therapies. Reducing Immunogenicity Immunogenicity, the ability of a substance to provoke an immune response, is a significant concern in biopharmaceuticals. ...
This feature is particularly advantageous for studying the effects of mutations and developing personalized therapies for genetic disorders. Unlike traditional gene editing methods that can be limited in their scope, custom mRNA production enables researchers to design precise alterations in gene expression, opening up new avenues for genetic research and ...
BiologicsFor biologic drugs (such as monoclonal antibodies or protein-based therapies), patients may develop anti-drug antibodies (ADA), which can neutralize the potency of the drug or accelerate its clearance from the body, thereby reducing efficacy or increasing the risk of side effects.2. ...
The prospects of novel drug candidates and customized therapies are emerging, heralding a future where personalized medicine is no longer a distant dream but a tangible reality. ...
The quest for transformative cell and gene therapies has ignited a wave of innovation in biopharmaceuticals. As the industry races to unlock these treatments’ full potential, the intricacies of therapy development present unprecedented challenges. ...
The fast-tracking landscape of contemporary gene therapy demands continuous advances in AAV (Adeno-associated virus) formulation development and the enhancement of cGMP (Current Good Manufacturing Practice) capacity. Together, these transformations are essential in producing safe and effective gene therapies for patients. AAV Formulation ...
Following with the early detection and diagnosis of rare diseases, the next step is developing effective treatments. Excitingly, recent advancements in gene engineering and drug R&D have led to the development of rare disease gene therapy and small-molecule drugs. ...
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options. While WNT/β-catenin signaling plays a crucial role in lung development and maintenance of adult lung stem cells, its dysregulation has been associated with pulmonary fibrosis. However, recent ...
Recombinase Adeno-Associated Virus (rAAV) particles have taken the center-stage in gene therapy research and development due to their exceptional genetic manipulation capabilities, safety and unprecedented therapeutic success. ...
Introduction In the world of molecular interactions, understanding the forces that drive binding events is crucial for advancing scientific research and developing new therapies. One powerful technique that has revolutionized the study of molecular interactions is Microscale Thermophoresis (MST). ...
Individuals with germline mutations in the CDH1 gene have a significantly increased risk of developing HDGC. Understanding the mechanisms underlying CDH1 loss and its impact on cancer progression is crucial for developing targeted therapies and improving patient outcomes. ...
Individuals who inherit the mutated gene are at risk of developing CMT2A, while those who do not inherit the mutation will not be affected. ...
These diseases often come with significant challenges, including accurate diagnosis, availability of effective treatments, and limited resources for research and development. However, recent advancements in diagnostics technology hold promise for speeding up the field of rare disease therapies. ...
What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. As a "living" drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted ...
Two types of gene therapy have the potential to treat CF, including non-integrated and integrated gene therapy. ...
These biomarkers aid in disease classification, patient stratification, and the development of targeted therapies, paving the way for precision medicine. Drug Discovery and Development: DGE analysis facilitates the identification of genes responsive to specific drug treatments. By unraveling the molecular mechanisms underpinning drug response, ...