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Tissue Accumulation And Species Specific Articles & Analysis: Older
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In recent years, messenger RNA (mRNA) technology has emerged as a revolutionary approach in the field of medicine, particularly in vaccine development and gene therapy. The ability to deliver mRNA effectively to target cells is crucial for harnessing its potential in treating a variety of diseases, including infectious diseases, cancer, and genetic disorders. This article explores the latest ...
Nanobodies, also known as single-domain antibodies, have gained much attention in recent years due to their potential in various biomedical applications including drug delivery systems. Nanobodies are small antibody fragments derived from naturally occurring heavy-chain antibodies found in camelids, such as camels and llamas. They are composed of a single monomeric variable domain, making them ...
What Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be ...
Dendrimers are highly branched polymers with a three-dimensional structure. They are characterized by expansive functional groups on their surface, which can be tailored to interact with specific molecules or to be used in a variety of applications. Dendrimers have attracted much attention in drug delivery, imaging, and materials science due to their unique structure, high monodispersity, and ...
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific ...
Recombinase Adeno-Associated Virus (rAAV) particles have taken the center-stage in gene therapy research and development due to their exceptional genetic manipulation capabilities, safety and unprecedented therapeutic success. As biomedical science advances, there is an ever-increasing enthusiasm in the usage of rAAV particles as effective vehicles for gene delivery and the subsequent therapy. ...
Targeted liposomes Coating the surface of liposomes with hydrophilic polymers such as polyethylene glycol is an easy way to achieve targeted drug delivery, which tends to minimize subsequent uptake by the reticuloendothelial system and therefore Circulation time is longer for passive accumulation in cancer tissue. In addition, various active substances can be ...
The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to be used to produce monoclonal antibodies, that the era of ADC drug development truly began. Driven by increasingly mature technology, ADC drugs have gone through three iterations (Fig. 1). Although ADCs have gone through three iterations, current ...
In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell's own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods. Apart from PROTAC, various targeted protein degradation (TPD) strategies are emerging, involving molecular glue, Autophagy-Targeting Chimera (AUTEC), Autophagosome Tethering Compound ...
What Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be ...
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture technology to enrich DNA from the whole exome regions, enabling high-throughput sequencing. WES offers a simpler, more cost-effective, ...
The clinical presentation of COVID-19-related illness ranges from asymptomatic to mild respiratory symptoms resembling influenza infection to acute symptoms including pneumonia requiring hospitalization and admission to the intensive care unit. COVID-19 starts in the upper airways and lungs, but in severe cases can also affect the heart, blood vessels, brain, liver, kidneys, and intestines. ...
Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics research. At the moment, Illumina, Ion Torrent/Life Technologies, 454/Roche, Pacific Bioscience, Nanopore, and GenapSys are all NGS platforms that can be used. They can produce reads of 100–10,000 bp in length, enabling sufficient coverage of the genome at a ...
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. In the 1930s, some scholars reported that the determination of serum lipase and alkaline phosphatase activities is helpful for the diagnosis of pancreatitis and bone diseases, respectively. After the 1950s, the application of serum ...
The Challenge: To understand the molecular effect of a ph-3 drug (Drug A) which showed moderate outcomes and to recommend next steps to increase response ...
The Challenge: With a drug in pre-clinical stage, our client was looking for the first indication to go into clinical ...
Abstract Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping2,3,4,5, but the ability to capture spatial epigenetic information of tissue at the cellular level and genome scale is lacking. Here we ...
Background Pancreatic cancer is one of the highest mortality rate cancers worldwide with 5-year relative survival of 10.8%. Lack of screening methods for early-stage detection as well as proper patient sub-characterization, make it a fatal cancer due to poor diagnoses and insufficient treatment. Methylation flags are kept on tumorigenesis, akin to the tissue-specific traces that are acquired and ...
RVx201 Herpes Vaccine Description 2022 RVx201 is a first-in-human herpes simplex virus type 2 (HSV-2) live-attenuated therapeutic vaccine modified to be interferon sensitive that destroys the ability of the virus to inhibit immune responses. Produced by Rational Vaccines, Inc., the technology is based on the pioneering research of the late Dr. William Halford, who dedicated over 25 years to ...
Liposomes have a phospholipid bilayer structure similar to cell membranes. Liposomes are closed ultramicrospheres, similar to an organelle-free artificial cell (only with cell membranes). The artificially manufactured liposome structure is also very similar to the exosomes and vesicles existing in nature. It is precisely due to this property similar to biofilm that it can be used as an efficient, ...