Tumor Characteristic Articles & Analysis: Older
12 articles found
The large T antigen of SV40 has the capability to bind and inactivate tumor suppressor proteins such as p53 and Rb, which are critical regulators of the cell cycle. ...
This modification system plays a crucial role in cellular biological processes such as tumor metabolism and immune regulation while also shaping the tumor microenvironment through control of translation efficiency and mitochondrial function along with tRNA fragment generation. ...
FAP-targeted therapeutics development services meet these challenges by generating full-spectrum therapeutic solutions that match the distinct biological characteristics of different tumors. The solutions target FAP for its overexpression across multiple cancer forms to engineer solutions which channel therapeutic agents straight to cancer cells while protecting ...
Circulating Tumor Cells, or CTCs, are cancer cells that have shed from the primary tumor and enter the bloodstream, where they can travel and potentially lead to metastasis. These cells are of significant interest in oncology due to their potential to provide vital information about the tumor’s characteristics and behavior. ...
This is typically performed using techniques like flow cytometry and radiolabeled binding assays. 3. Tumor Inhibition Potency Analysis ServiceOnce binding characteristics are established, the next step is to assess tumor inhibition potency. ...
In cancer, the heterogeneity of tumors often results in a subset of cells that can survive initial treatments, leading to relapse and metastasis. ...
PDX models involve implanting human tumor tissues into immunocompromised mice, allowing researchers to study tumor growth and response to treatment in a living organism. These models retain the genetic and phenotypic characteristics of the original human tumors, providing insights into how different therapies may perform in ...
Alfa Cytology’s Ovarian Cancer Therapy Development Services aim to bridge this gap by offering highly customized, robust therapeutic solutions that correspond with ovarian tumors’ unique biological and molecular characteristics. These services include developing targeted therapies, immunotherapy, and inhibitors and drugs. ...
Zebrafish and mammals share common molecular pathways for tumor progression. Likewise, more than 130 different genes in zebrafish liver tumors exhibited expression similar to those characteristic of human liver cancers, correlating with histological tumor type, grade, and stage. ...
They can increase glucose and glutamine uptake and perform aerobic glycolysis, resulting in high lactate and low ATP production. However, tumors are heterogeneous, and each tumor has its own metabolic characteristics. Even different tumor cells within the same tumor differ in their metabolic patterns. ...
Brain tumors can be broadly categorized into primary and secondary (or metastatic) tumors. Primary tumors originate in the brain1, while secondary tumors spread from other body parts. ...
Its high expression is associated with the occurrence of many tumors and poor prognosis. It is a very popular ADC research target, second only to HER2. ...