Refine by
Tumor Microenvironment Articles & Analysis: This-Year
9 articles found
In oncology, CCR1-mediated chemotaxis is increasingly recognized as a driver of the tumor microenvironment. Tumor-associated fibroblasts and macrophages often express CCR1, where they help establish pro-tumor niches by promoting angiogenesis and suppressing anti-tumor immunity. ...
This modification system plays a crucial role in cellular biological processes such as tumor metabolism and immune regulation while also shaping the tumor microenvironment through control of translation efficiency and mitochondrial function along with tRNA fragment generation. ...
One of the most significant applications lies in cancer immunotherapy. Tumors often manipulate chemokine pathways to evade immune surveillance. By administering recombinant chemokines, scientists can redirect immune cells to the tumor microenvironment, potentially enhancing the efficacy of checkpoint inhibitors or CAR-T cell therapies. For ...
The complex nature of cancer treatment highlights the critical requirement for therapies that show both effectiveness and precise targeting of tumor biology. The conventional treatment approaches fail to accurately target cancer cells, which results in numerous adverse effects while diminishing treatment success. ...
During in vitro incubation researchers can administer interferon-γ-inducible protein 10 (IP10) inside platelets. Within the tumor microenvironment elevated levels of thrombin activate the IP10-platelet complex which releases its drug payload leading to substantial anti-tumor results. The IP10-loaded platelets targeted and inhibited ...
The firm develops monoclonal antibodies that target tumor-specific antigens through the services. This method shows potential for better patient response rates while simultaneously enabling the detection of tumor progression and resistance mechanisms. ...
The monoclonal antibody is designed to bind specifically to cancer cells, ensuring that the toxic drug is delivered directly to the tumor, thereby minimizing damage to healthy cells. This targeted approach enhances the therapeutic index of the drug, resulting in improved efficacy and reduced side effects compared to conventional chemotherapy. ...
Their roles span across embryonic development, wound healing, angiogenesis, and tumor progression. Measuring growth factor levels in biological samples is crucial for understanding how cells communicate and adapt to physiological changes or pathological insults. ...
Researchers use these models because they retain many of the biological properties of the original tumors, thus providing insights into the cancer’s behavior. The establishment of cell lines involves extracting cancer cells from a tumor biopsy, followed by their growth in a nutrient-rich medium under sterile conditions. ...