Molecular phylogenetics of Candida Albicans

Mar. 23, 2007- By: Marie-Elisabeth Bougnoux, Duncan J. Shaw, Judith M. Bain, Amanda D. Davidson, Dorothe´e Diogo, Mette D. Jacobsen, Maud Lecomte; Frank C. Odds

Courtesy ofAmerican Society for Microbiology (ASM)

Candida albicans is the most frequently encountered among the Candida species lbicans is a diploid species without sexual morphology and with substantial heterozygosity (48). Its predominant mode of reproduction is clonal (1, 23, 37, 41, 52), but it can occasionally undergo recombination (1, 23, 65), mitotic crossing over (48), and ploidy changes based on chromosome loss and reformation (58, 72). These contribute to the genomic microvariation that has been documented for multiple C. albicans isolates from single patients (8, 37, 47, 50, 56).