Ab Studio Inc. services

Construction of Fv homology and Fv hetero models based on. Schrodinger`s equation. Generation of an aggreagate surface report. Generation of a PTM analysis report (including N-glycosylation, deamidation, oxidation and protease site analysis based on the displaying status of the amino acids on 3D structure surface). pI prediction using the 3D structure.

1D antibody sequence analysis service with licensed software and in-house tools.

3D Computer-aided antibody structure analysis service based on advanced AI protein modeling software (AlphaFold) and antibody design expertise.

Humanization percentage, CDR Immunogenicity, Antigen binding affinity, Antibody expression level, Aggregation potential,  Antibody stability, Heterogenicity.

Detailed sequence analysis and 3D structure modeling. Identification of the best human germline sequence templates and grafting the rodent or rabbit antibody CDR regions into the human antibodyframeworks. Identifying back- mutations and removing “hot spots” with developability issues. High-throughput lead selection and evaluation. Efficient lead preparation for research purposes in-house (up to 20mg) and CMC level protein preparation at partner facilities.