Absolute Antibody Ltd services

Absolute Antibody offers a quick and professional hybridoma sequencing service, also known as antibody sequencing. Hybridoma sequencing is the sequencing of the cDNA encoding the variable heavy (VH) and variable light (VL) domains of your hybridoma cell line.

Humanization is a critical step in the development pathway of all therapeutic antibodies derived from non-human sources, such as hybridomas. Absolute Antibody’s Prometheus™ antibody humanization service delivers a panel of humanized variants from your clone, guaranteeing to produce a variant with comparable activity to the parent antibody. Our service focuses on enhancing antibody manufacturability, leading to increased expression, lower aggregation, and long-term stability and solubility.

Binding multiple epitopes with a single antibody offers several benefits. For example, one specificity may target individual molecules while another could recruit effector cells or deliver a drug to the target. Other options include dual-target bispecifics which might detect a desired cell type with much higher selectivity than a monospecific antibody. One of Absolute Antibody’s engineering services is the design and manufacture of multispecific antibody formats. Starting with a hybridoma cell line or antibody sequence, we can deliver from milligrams to grams of your custom bispecific, 100% royalty-free.

Polyclonal antibodies are widely used reagents across research and diagnostics. They are generated by immunizing animals with an immunogen and harvesting the animals’ blood to obtain immunoreactive serum. While polyclonal antibodies offer a range of advantages such as excellent performance across different methods, they suffer from high batch-to-batch variability and require the continued use of animals for their production.