AdAlta Limited products

AdAlta is utilising the power of the i-body technology platform to develop a growing pipeline of i-bodies to treat a range of conditions, with an initial focus on treating fibrotic diseases. AdAlta identified an i-body that binds to the drug target, CXCR4 and demonstrates anti-fibrotic effects in several models of fibrosis. This was initially called AD-114.  Following further development, AdAlta has improved the initially identified i-body through redesign as an Fc-Fusion molecule, now named AD-214. The new i-body has shown significantly enhanced activity, providing the potential application for a wider range of fibrotic diseases.

AdAlta and Carina Biotech to develop next-generation i-body enabled CAR-T cancer therapeutics. AdAlta has entered a collaboration agreement with Carina Biotech to develop next-generation i-body enabled CAR-T cells, with the potential to bring CAR-T cell therapy to treat a far greater range of cancers than the small number of blood cancers that has been achieved today. Under the Collaboration Agreement, AdAlta will discover and optimise panels of i-bodies that bind to designated solid tumour antigen targets, from which Carina will generate CAR-T cells and identify optimal CAR-T product candidates including bi-specific CAR-T products. Carina and AdAlta will jointly fund pre-clinical proof of concept studies in mouse tumour models and will jointly own products emerging from the collaboration.