ALPHA-1 BIOLOGICS LLC news

Alpha-1 Biologics, a biotherapeutics company developing innovative treatments for cancers and immune deficiencies, today announced that positive data was published in frontiers in Oncology demonstrating Alphataxin, a small molecule that elevates circulating and tumor-infiltrating CD4+ T cells, suppressed kidney cancer and suppressed metastasis in mice. Orally available Alphataxin, is the first and only drug in development to increase formation of CD4+ helper T cells. Immune checkpoint inhibit

Investigators discuss in "a(1)Proteinase Inhibitor Regulates CD4 Lymphocyte Levels and Is Rate Limiting in HIV-1 Disease" new findings in HIV/AIDS. According to the authors of recent research from New York City, New York, "The regulation of adult stem cell migration through human hematopoietic tissue involves the chemokine CXCL12 (SDF-1) and its receptor CXCR4 (CD184). In addition, human leukocyte elastase (HLE) plays a key role." "When HLE is located on the cell surface (HLE(CS)), it a

According to recent research from New York, HLE "interacts with HIV-1 glycoprotein (gp)41, suggesting a nonenzymatic receptor function for HLE in the context of HIV-1." "HLE is found localized to the cell surface, but not granules in HIV permissive clones, and to granules, but not the cell surface of HIV nonpermissive clones," noted C.L. Bristow and coauthors at Rockefeller University.