AMEGA Biotech products

Pegylated form of recombinant Escherichia coli (E. coli)-expressed interferon alfa-2b protein. Pegylation involves the covalent linkage of a single inert straight-chain polyethylene glycol (PEG) polymer strand , which protects the molecule in vivo from proteolytic breakdown, substantially increases its in vivo half-life, and reduces immunogenicity.

Interferons are a group of antiviral proteins produced in reaction to viral infections. It boosts the resistance of surrounding cells to attacks by viruses, inhibits viral multiplication and modifies the body’s immune response. Interferon alfa is the type that has been found to be most useful in the treatment of certain forms of cancer, including metastatic renal cell carcinoma and hairy cell leukemia. Interferon alfa-2b was also the first molecule to be approved for chronic hepatitis B. Interferon alfa-2b is a recombinant, non-glycosylated alfa interferon protein expressed by Escherichia coli (E.coli) transformed with the gene for Interferon alfa-2b from human leukocytes. It is a type I water-soluble interferon consisting of 165 amino acids and has a molecular weight of 19,271 Daltons (19,271 kDa).

Interferons are a group of antiviral proteins produced in reaction to viral infections. It boosts the resistance of surrounding cells to attacks by viruses, inhibits viral multiplication and modifies the body’s response. Interferon beta is produced by fibroblasts. It is used in the treatment of multiple sclerosis. Interferon beta-1a is a human recombinant glycoprotein expressed by Chinese hamster ovary (CHO) cells transformed with the human interferon beta-1a gene. The amino acid sequence of human Interferon beta-1a is identical to that of human fibroblast-derived Interferon beta-1a. CHO-expressed Interferon beta-1a is a 166 amino acid glycoprotein with a predicted molecular weight of approximately 22,500 Daltons (22.5 kDa). Its glycosylation is similar to that of human Interferon beta-1a, and occurs at the asparagines (Asn) residue at position 80.

A recombinant antibody-like fusion protein (TNFR2-IgG1 Fc) consisting of the soluble extracellular ligand-binding domain of human tumor necrosis factor receptor-2 (TNFR2) linked to the constant (Fc) region of human immune globulin G1. It is expressed as disulfide-bound dimers in transformed Chinese hamster ovary (CHO).

Interferons are a group of antiviral proteins produced in reaction to viral infections. It boosts the resistance of surrounding cells to attacks by viruses, inhibits viral multiplication and modifies the body’s immune response. Interferon alfa is the type that has been found to be most useful in the treatment of certain forms of cancer, including metastatic renal cell carcinoma and hairy cell leukemia. Interferon alfa-2a refers to a recombinant, non-glycosylated, N-terminal methionine alfa protein expressed in Escherichia coli (E.coli). Recombinant Interferon alfa-2a is a purified protein containing 165 amino acids, and it has an approximate molecular weight of 19,000 daltons.