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It has been shown that changes of intracellular levels of S-adenosylmethionine (SAM) are related to the well beings of cells and organisms. The fluctuation of SAM level is cause by imbalance between SAM synthesis and metabolic pathways (methylation, transsulfuration and aminiopropylation) or degradation. S-adenosylmethionine biosynthesis is strictly and solely dependent on the activity of Methionine Adenosyltransferase (MAT, E.C.2.5.1.6), also known as S-adenosylmethionine synthetase. The methionine adenosyltransferase is encoded by two genes, MAT1A and MAT2A, encode for two homologous MAT catalytic subunits, α1 and α2. MAT1A is expressed in normal liver, and it encodes the α1 subunit found in two native MAT isozymes, which are either a dimer (MAT III) or tetramer (MAT I) of this single subunit.

SAM analog and antibody: One of the important S-adenosylmethionine (SAM) analogs has a very good thermostability and yet a high hygroscopicity. This analog can also be used as a standard in in intro assays of SAM.

S-adenosylmethionine (SAM) is an important molecule in methionine cycle pathway and one carbon metabolism pathway that are implicated in many metabolic abnomalities found in humans. Methylation index is defined as the ratio of SAM and SAH, which is a better way to evaluate methylation status of humans and other organisms. The level of S-adenosylmethionine (SAM) fluctuates depending on age, gender, race, body weight, diet, medicines taken, health and disease conditions. The internal unstable nature of SAM molecule and the dynamics of methylation process from an in vivo environment make measuring its de-methylation product S-adenosylhomocysteine (SAH) critical in the process of evaluating the status and extent of biochemical methylation process in a living body.