Biopeptek Pharmaceuticals LLC products

Biopeptek is a leading manufacturer of synthetic peptide Active Pharmaceutical Ingredient (API). We offer custom APIs for pharmaceutical research & development organizations world-wide to support pre-clinical and clinical studies. We also support our clients for preparation of Chemistry, Manufacturing and Controls (CMC) regulatory documentation.

Pegylation is the process of covalent attachment of polyethylene glycol (PEG) polymer chains to another molecule, normally a drug or therapeutic peptide or protein. Pegylation is routinely achieved by incubation of a reactive derivative of PEG with the target macromolecule. The covalent attachment of PEG to a drug or therapeutic peptide or protein can “mask” the agent from the host’s immune system (reduced immunogenicity and antigenicity), increase the hydrodynamic size (size in solution) of the agent which prolongs its circulatory time by reducing renal clearance. Pegylation can also provide water solubility to hydrophobic drugs and peptide synthesis or proteins.

N-Methylation is the substitution of the N-alpha proton with a methyl group on the peptide backbone. N-Methyl scanning refers to the systematic N-methylation of each amino acid in a given sequence. It is applied to a peptide antigen or peptide in order to enhance its efficacy and stability. Biopeptek has the necessary expertise in this relatively new procedure.