Brevetti Angela S.r.l. products

The SYFPAC SVP system specializes in the aseptic primary packaging of small volume parenterals, ideal for vials and ampoules ranging from 0.2ml to 50ml. This machine supports the production of both single-use and multi-dose containers at a production speed of up to 16,000 units per hour, with potential upgrades to 25,000 units. Its design reduces clean room dimensions to 36 sqm and requires only class C or D environments. Offering high flexibility, it accommodates materials like PP, PE, and HDPE, optimizing resistance to sterilization and product stability. The machine supports a variety of solution types, from vaccines to heat-sensitive products, with advanced features like nitrogen filling, automatic CIP and SIP, and a user-friendly HMI. The SYFPAC SVP is suited for 24/7 operation with robust maintenance tracking, enhancing reliability and efficiency in pharmaceutical production.

The SYFPAC® LVP is an advanced machine designed for aseptic primary packaging of large volume parenterals in plastic bottles ranging from 50ml to 1000ml, with designs accommodating up to 2500ml for specialized applications. It is engineered to produce self-collapsible bottles, versatile in filling various formulations. This machine exhibits a high production rate, capable of handling up to 2,700 bottles per hour, making it suitable for continuous, high-volume production. The robust system incorporates features like a smart preventive maintenance program, automatic inert gas filling, and an advanced SCADA system for efficient management. It offers flexibility with modular moulds adaptable to various designs and materials such as PE, PP, and HDPE. Its compact size reduces clean room requirements, and it allows for configurations like implementable capping solutions using Eurocap and Ecohead designs. Essential applications include intravenous solutions, irrigation, sodium chloride, and glucose.

The SYFPAC SVP TWIN machine is engineered to significantly enhance the production of small volume parenterals (SVP) by employing a unique double-decker mould design, achieving a 60% increase in productivity without additional floor space or clean room expansion. Catering to a volume range of 0.2ml to 20ml, it is suited for single-use containers and multi-dose vials. The machine maintains the same utility requirements as the traditional SYFPAC SVP while boosting cost efficiency. It is capable of producing up to 27,000 units per hour and features modular moulds for various container designs, including diverse closure options and labeling space. Designed for heat-sensitive products, it supports solutions from 4°C to 30°C and accommodates high-viscosity liquids. Its robust construction facilitates 24/7 operation with preventive maintenance protocols. With capabilities to handle PP, PE, and HDPE materials, the SYFPAC SVP TWIN offers flexibility in packaging with enhanced vial squeezability and reduced plastic consumption.

The SYFPAC SECUREJECT system is employed for the production of prefilled syringes and injection devices using Blow-Fill-Seal (BFS) technology. Ideal for mass production, it can produce syringes ranging from 0.5ml to 20ml sizes swiftly, forming, filling, and sealing each unit under aseptic conditions in just 16 seconds. The versatile machinery handles different polymers such as PP, PE, and HDPE, and does not require mold changes, thus optimizing operational efficiency. Its compact design needs minimal cleanroom space, requiring only a Class C environment for operation. The machine's production rate reaches up to 5,100 units per hour, and it can run continuously to meet demanding production schedules. Moreover, it can safely handle temperature-sensitive formulations, making it suitable for a variety of applications including vaccines, injectables, and biologicals. The system integrates a user-friendly HMI and adheres to CFR 21 requirements, ensuring data integrity and a reliable operation that minimizes risks and costs.