Creative Biogene products

The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3" of the DNA lesion while the ERCC1-XPF complex makes the 5" incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.

Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene. Endothelial NOS is a nitric oxide synthase that generates NO in blood vessels and is involved with regulating vascular tone by inhibiting smooth muscles contraction and platelet aggregation. A constitutive calcium dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golqi bodies within cells.

Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene. Endothelial NOS is a nitric oxide synthase that generates NO in blood vessels and is involved with regulating vascular tone by inhibiting smooth muscles contraction and platelet aggregation. A constitutive calcium dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golqi bodies within cells.

Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene. Endothelial NOS is a nitric oxide synthase that generates NO in blood vessels and is involved with regulating vascular tone by inhibiting smooth muscles contraction and platelet aggregation. A constitutive calcium dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golqi bodies within cells.

This is a stable cell line that is engineered to constitutively express dog ATP binding cassette subfamily B member 1 (ABCB1) in MDCK cells. The expression of dog ABCB1 in this cell line has been validated by real-time qPCR and western blot analysis. This cell line is a valuable cell model for investigating dog ABCB1 functions and screening assays.

This cell line is engineered to stably produce Rituximab which is a monoclonal antibody against human MS4A1/CD20.

This cell line is engineered to stably produce Trastuzumab which is a monoclonal antibody against human ERBB2/HER2.

This cell line is engineered to stably produce Cetuximab which is a monoclonal antibody against human EGFR.

This cell line is engineered to stably produce Nivolumab which is a monoclonal antibody against human PDCD1/PD1.

CB-0010 mini vortex mixer is a routine mixing equipment for biochemistry, chemistry laboratory, hospital and etc.