Emulate products

Zoë sustains the life of cells within our Organ-Chips, automating the precise conditions needed to culture up to 12 Organ-Chips.

Investigate mechanisms of colon inflammation and barrier disruption and evaluate the efficacy of anti-inflammatory drug candidates in an organoid-derived model.

Study lung physiology, disease, and the effect of drug candidates. A more human-relevant model for studying pulmonary physiology, with primary human cells in a lung-specific microenvironment. We are currently developing two distinct models of the human lung—the Alveolus Lung-Chip and the Airway Lung-Chip—to capture the specific tissue architecture and function of different lung tissues. Both models will enable researchers to investigate pathophysiology and evaluate drug effect during preclinical discovery and development.

Investigate mechanisms of toxicity for preclinical drug candidates to help decrease clinical trial safety failures. Drug-induced liver injury (DILI) is a primary concern during drug development that remains poorly understood due to species differences in liver toxicity and the limited predictivity of conventional in vitro models. The quad-culture Emulate Liver-Chip combines four human cell types in a dynamic microenvironment to support in vivo like gene expression, functionality, and physiology. Applications include general and mechanistic toxicity evaluation, as well as biomarker identification and mechanism of action determination.

Evaluate drug candidate toxicity at clinically relevant concentrations in a co-culture human kidney model. Predicting drug-induced kidney toxicity and drug-drug interactions continues to be a challenge due to a reliance on immortalized cell line culture or animal models that do not translate to human response. The co-culture Emulate Kidney-Chip combines primary human cells in a dynamic microenvironment for an improved model of the proximal tubule-peritubular capillary interface. Applications include preclinical toxicity testing of drug candidates across a diverse array of endpoints.