Genetic Signatures Ltd. products

In the United States (US), gastrointestinal (GI) protozoan parasites are a significant healthcare burden, with more than 350 million cases of acute GI infections annually. Globally, protozoan infections are the leading cause of mortality of children under five years old.^1,2 Hence, the importance of rapid and accurate diagnosis and treatment is essential for decreasing the significant burden of GI infections. The Center for Disease Control and Prevention (CDC) recorded a steady increase in reported GI protozoan outbreaks in the US over the past 12 years until 2020 (refer to the chart below). At this point, COVID-19 restrictions significantly decreased outbreaks due to reduced mobility, and decreased local and international travel. However, now that restrictions have lifted, reported weekly parasite infections from the National Notifiable Diseases Surveillance System (NNDS) indicate a lift in reported cases in early 2022.

The EasyScreen™ Essentials Respiratory Detection Kit enables multiplex real-time PCR testing for leading viral pathogens that cause respiratory tract infections, including SARS-CoV-2. A full list of the essential respiratory pathogen targets is listed in the table below. User friendly medium to high-throughput systems are available that support Genetic Signatures’ full range of unique 3base™ assays for detecting infectious disease. This patented 3base™ technology has many advantages over conventional 4-base assays, including improved sequence similarity for the detection of pathogen subtypes or gene families, and increased ‘immunity’ to potential genetic mutations, as seen in SARS-CoV-2.

The STI Genital Pathogen and Reproductive Health Reagents are rapid in vitro nucleic acid amplification assays for the qualitative detection of sexually transmitted pathogens as well as commensal and reproductive health-associated bacteria.

Beta-lactam antibiotics are the most commonly used antibiotics worldwide for the treatment of bacterial infections. Extended Spectrum Beta-Lactamase (ESBL) producing organisms hydrolyze cephalosporins, penicillins, and aztreonam, rendering them ineffective for the treatment of infected patients. This makes accurate and timely detection of ESBL and Carbapenemase Producing Organisms (CPO) important as it will have a significant impact on patient management.

Carbapenem based antibiotics have become the first line choice in the treatment of ESBL infections. Of significant global concern therefor is the emergence of carbapenem resistant (CPO) bacteria in healthcare settings, as standard treatments may be rendered ineffective.

Viral meningitis can be caused by a number of viruses, including Herpesviruses, Human Parechovirus and Enterovirus.  It is a common infection that causes “flu-like” symptoms, and is usually self- limiting, hence it does not require specific treatment in most cases. Rapid diagnosis is important however, to rule out a more serious bacterial meningitis infection, and to provide support to high-risk patients. Molecular detection methods offer the advantages of speed, and ability to screen for a larger number of pathogens than conventional methods.

Bacterial meningitis develops quickly and requires immediate medical attention, as it can be fatal without prompt treatment. Several types of bacteria can cause meningitis. The Genetic Signatures` Bacterial Meningitis ASRs have been designed to detect the most common bacterial meningitis-causing infections.

Fungal meningitis is rare and can develop after a fungus spreads from somewhere else in the body to the brain or spinal cord. The Genetic Signatures Fungal Meningitis ASRs has been designed to detect a common fungal causing pathogen.