Immudex ApS products

Antigen-specific CD8+ T cells play an important role in the immune response of autoimmune disease, cancer, transplantation, infectious disease, and allergy. MHC I Dextramer® reagents can identify antigen-specific CD8+ T cell subsets by flow cytometry. MHC I Dextramer reagents consist of a protein-stabilizing dextran backbone, an optimized number of MHC-peptide complexes, and fluorophores (PE, APC, or FITC) no fluorophore (None). Immudex manufactures MHC I Dextramer reagents as listed in the table below. Customized reagents are easily made with MHC alleles from our catalog and with peptides that form stable complexes with the MHC molecule.

Antigen-specific CD4+ T cells play an important role in the immune response of autoimmune disease, cancer, transplantation, infectious disease, and allergy. MHC II Dextramer® reagents can identify antigen-specific CD4+ T-cell subsets by flow cytometry. MHC II Dextramer reagents consist of a protein-stabilizing dextran backbone, an optimized number of MHC-peptide complexes, and fluorophores (PE, APC or FITC) or no fluorophore (None). Immudex manufactures MHC II Dextramer reagents as listed in the table below. Customized reagents are easily made with MHC alleles from our catalog and with peptides that form stable complexes with the MHC molecule.

Visualize the Landscape of Tissue-Specific Immunity. Tracking T cells in the tissue where they exert their function can advance our understanding of T-cell immunity. MHC I Dextramer® for in-situ staining reagents can detect spatial distribution, localization, and abundance of antigen-specific T cells in different tissue sites in health and disease.

Reliable Identification of SARS-CoV-2-Specific T-Cell Responses. T Cells Take the Lead in COVID-19. A deeper understanding of viral-specific T-cell responses to COVID-19 is needed to explore vaccine responses, long-term immunity, predict patients at risk, and even prepare for the next pandemic. T-cell responses are believed to be important for protection against severe disease through the development of long-term immunity. SARS-CoV-2-specific CD4+ and CD8+ T cells are present for at least a year after infection with COVID-19. Functional T cells targeting multiple antigens of SARS-CoV-2 are detected in mild and severe COVID-19, as well as asymptomatic individuals.

dCODE Dextramer technology enables the analysis of antigen-specific T cells by NGS or single-cell multi-omics. dCODE Dextramer adds a unique DNA barcode to the MHC Dextramer® reagent to detect antigen-specific T cells by NGS or single-cell multi-omics. High-avidity binding to T-cell receptors thanks to multiple MHC-peptide complexes. High-throughput screening with a unique barcode for each MHC-peptide specificity. Enrichment of low-frequency cells thanks to PE fluorochromes. Compatible with single-cell gene expression analysis.