ImmunoVision, Inc. products

The dsDNA antigen is a 2690 bp plasmid purified by alkaline lysis and chromatography. The purification process includes operations to minimize reactivity to antibodies against single-stranded DNA. Use of plasmid DNA in ELISA is an effective method for the detection of anti-double-stranded (ds) DNA antibodies (1). The presence of antibodies to dsDNA is included in the 1982 revised criteria for classification of Systemic Lupus Erythematosus (SLE) (2).

Histones are a group of similar, small, highly conserved nuclear proteins that bind to DNA by their many basic residues. The histones are divided into fractions, with each fraction having a distinct amino acid composition and sequence. Histones are also classified by relatively high levels of lysine and arginine. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were to H1, H2b, and H3. Marked elevations of binding occurred to H1 and H2b in 33% of patients, while 25% showed higher binding to H3 (2). The same study showed the highest anti-histone reactivity to be in patients with rheumatoid arthritis with vasculitis, while the highest reactivity in SLE sera was in those patients with a history of photosensitivity (3).

Histones are a group of similar, small, highly conserved nuclear proteins that bind to DNA by their many basic residues. The histones are divided into fractions, with each fraction having a distinct amino acid composition and sequence. Histones are also classified by relatively high levels of lysine and arginine. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were to H1, H2b, and H3. Marked elevations of binding occurred to H1 and H2b in 33% of patients, while 25% showed higher binding to H3 (2). The same study showed the highest anti-histone reactivity to be in patients with rheumatoid arthritis with vasculitis, while the highest reactivity in SLE sera was in those patients with a history of photosensitivity (3).

Histones are a group of similar, small, highly conserved nuclear proteins that bind to DNA by their many basic residues. The histones are divided into fractions, with each fraction having a distinct amino acid composition and sequence. Histones are also classified by relatively high levels of lysine and arginine. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were to H1, H2b, and H3. Marked elevations of binding occurred to H1 and H2b in 33% of patients, while 25% showed higher binding to H3 (2). The same study showed the highest anti-histone reactivity to be in patients with rheumatoid arthritis with vasculitis, while the highest reactivity in SLE sera was in those patients with a history of photosensitivity (3).

Chromatically purified mouse monoclonal antibody to the Y-F-V-P-P-K-E-D-F-K epitope of the Scl-70 antigen, Clone 17F2, Isotype IgG, K. For use in standard solid phase immunoassays.

The ImmunoVision donor program has obtained disease state plasmas of various specificities. If we do not list the specificity that you need, please contact us at 479-751-7005. ImmunoVision is continually adding new and different monospecific donors to this program. Pricing of plasma is based on volume and lot purchase. (Minimum 100ml purchase.) Each lot is one draw or unit from a single donor. An additional fee will be charged for splitting a unit or lot. The volume of each unit or lot varies, but is approximately 500 ml. As in all donor plasma, activity may vary among lots.

The ImmunoVision donor program has obtained disease state plasmas of various specificities. If we do not list the specificity that you need, please contact us at 479-751-7005. ImmunoVision is continually adding new and different monospecific donors to this program. Pricing of plasma is based on volume and lot purchase. (Minimum 100ml purchase.) Each lot is one draw or unit from a single donor. An additional fee will be charged for splitting a unit or lot. The volume of each unit or lot varies, but is approximately 500 ml. As in all donor plasma, activity may vary among lots.

Antibody against Histone, detectable by Western blot immunoassay at 1:100 dilution. Titer will vary with test system.

Antibody against human Jo-1, detectable bands at Jo-1 53kD by Western blot immunoassay at 1:100 dilution using Hep-2 cellular extract blot. Titer will vary with test system. No attempts have been made to qualify this product on blots made with HeLa cell, or any other antigen source. This product may have affinity for bands other than those mentioned.

Hepatitis B core recombinant antigen isolated from E. coli and purified by chromatographic methodologies. Description: Hepatitis B core antigen (HBcAg) is the major component of the core particles of Hepatitis B Virus (HBV). Particles have a size of 27 nm and contain a circular double-stranded DNA molecule, a specific DNA-polymerase and HBcAg.