InSphero AG products

Liver - Liver Disease

InSphero 3D InSight - Advanced Human Disease

The 3D InSight™ Steatosis Model is an advanced human disease model that enables you to screen compounds and investigate disease pathophysiology using a physiologically relevant human liver microtissue that recapitulates the first stage of non-alcoholic fatty liver disease: accumulation of lipids in liver hepatocytes. Available as an assay-ready model delivered to your lab, or for use in 3D InSight™ Discovery Services, this diet-induced steatosis model includes a microtissue produced from a co-culture of healthy primary human hepatocytes, Kupffer cells, and liver endothelial cells, combined with specially formulated media and a preparation of free fatty acids bound to bovine serum albumin for lipid-loading.

InSphero 3D InSight - Advanced 3D Human Liver Disease

Test efficacy of anti-NASH drugs in an advanced 3D human liver disease model. The InSphero 3D InSight™ Human Liver NASH Model consists of an advanced microtissue co-culture of healthy primary human liver cells combined with specially formulated media and cocktails that induce the progression of NAFLD and NASH from steatosis to liver inflammation and fibrosis. Ideal for investigating mechanisms of non-alcoholic steatohepatitis (NASH) induction, in vitro screening of anti-NASH drug efficacy, and safety assessment of drug candidates in a relevant disease background, this powerful model includes all the critical liver cells and inducers needed to recapitulate the progression of human fatty liver disease.