Inversago Pharma products

CB1 Agonist: A molecule binding to the CB1 receptor and activating a biological response (e.g.: seek food (increased appetite), slow down metabolism / gastric transit and reduce energy expenditure). Activation of the CB1 receptors is also involved in fibrogenesis.

CB1 Receptors: Signaling the Brain from the Periphery: The endocannabinoid system is responsible for both homeostasis and equilibrium of the human metabolism. It is involved in regulating several pathways linked to energy intake, reserves and overall expenditure. To do so, the cannabinoid-1 receptor (CB1) may be activated and deactivated such that it impacts many metabolic pathways involving several enzymes and proteins, e.g. leptin, insulin and ghrelin.

Inversago Pharma Inc. is focused on the development of peripherally-acting CB1 receptor (CB1) inverse agonists for the treatment of diabetic nephropathy, NASH, type 1 diabetes and Prader-Willi Syndrome. While previous generation of centrally-acting CB1 inhibitors presented safety concerns, the therapeutic relevance of peripheral CB1 pathway is still strongly supported by comprehensive scientific evidence and  remains to be fully exploited. CB1 receptor world expert Dr George Kunos from US NIH has extensively demonstrated that peripherally-acting CB1 blockade provides an equivalent therapeutic potential to treat metabolic conditions such as obesity/NASH/T2D and fibrosis (liver and lung), without targeting central CB1 receptors.