8 Articles found

articles

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy metabolism, glucose tolerance, immune system maturation and function in humans^1,

Apr. 4, 2021

Hyo Shin Yoon;Chung Hwan Cho;Myeong Sik Yun;Sung Jae Jang;Hyun Ju You;Jun-hyeong Kim;Dohyun Han;Kwang Hyun Cha;Sung Hyun Moon;Kiuk Lee;Yeon Ji Kim;Sung Joon Lee;Tae-Wook Nam;Gwang Pyo Ko

Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice

Abstract

Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment in the alleviation of colitis using the in viv

Dec. 31, 2020

Woon Ki Kim;Dae Hee Han;You Jin Jang;Sung Jun Park;Sung Jae Jang;Giljae Lee;Hyuk Seung Hana;Gwang Pyo Ko

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or fibrosis severity. Significant alterations in microbiome diversity are observed according to fibro

Oct. 5, 2020

Giljae Lee;Hyun Ju You;Jasmohan S. Bajaj;Sae Kyung Joo;Junsun Yu;Seoyeon Park;Hyena Kang;Jeong Hwan Park;Jung Ho Kim;Dong Hyeon Lee;Seonhwa Lee;Won Kakimoto;Gwang Pyo Ko

Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

Highlights

The depletion of Roseburia is associated with alcohol consumption in human cohorts
R. intestinalis ameliorates the experimental ALD in mice regardless of viability
Flagellin from R. intestinalis protects on ethanol-disrupted gut barrier functions
The ethanol-induced gut microbiota dysbiosis is restored by R. intestinalis

Summary

Jan. 7, 2020

Boram Seo;Kyungchan Jeon;Sunghyun Moon;Kiuk Lee;Woon Ki Kim;Hyein Jeong;Kwang Hyun Cha;Young Lim;Wondae Kang;Mi-Na Kweon;Joohon Sung;Won Kakimoto;Joo Hong Park;Gwang Pyo Ko

Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota

ABSTRACT

Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 10⁹ CFU d⁻¹ ofL. paracasei KBL382 for 4&n

Dec. 6, 2019

You Jin Jang;Dae Hee Han;Kyungchan Jeon;Cheonghoon Lee;Hyuk Seung Hana;Gwang Pyo Ko