KORU Medical Systems products

Chronic inflammatory demyelinating polyneuropathy, or CIDP, is a rare disorder characterized by gradually increasing sensory loss and weakness associated with loss of reflexes. This is caused by an autoimmune process in which the body’s own immune system doesn’t recognize its nerve fibers and attacks them.  This leads to inflammation of nerve roots and peripheral nerves, as well as the deterioration of the fatty protective covering (myelin sheath) over the nerves, affecting how fast the nerve signals are transmitted and leading to loss of nerve fibers.^1,2

Primary Immunodeficiency Diseases (PIDD) are a group of over 350 chronic disorders resulting from defects in the body`s immune system that are caused by hereditary or genetic defects. PIDD patients have an increased susceptibility to infection due to their defective immune response, enduring recurrent health problems and often developing serious illnesses. With proper medical care, many patients can live full and independent lives.^{1, 2}

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, life-threatening blood disorder characterized by the complement-mediated destruction (hemolysis) of oxygen-carrying red blood cells. The disease is caused by a genetic mutation in the DNA and causes red blood cells to be missing a critical protein responsible for protecting them. Hemolysis occurs in PNH through two mechanisms: intravascular hemolysis (IVH), which occurs inside blood vessels, and extravascular hemolysis (EVH), which occurs in the liver and spleen. Both types of hemolysis are responsible for the symptoms of PNH. When red blood cells break apart, hemoglobin (carries oxygen around the body) is eliminated in urine. Low hemoglobin leads to low oxygen, which causes symptoms like fatigue, headache, and shortness of breath.