Magenta Medical Ltd. products

The Magenta percutaneous Left Ventricular Assist Device (pLVAD) is a self-expanding percutaneous catheter-mounted arterial pump that is intended to provide temporary mechanical circulatory support for the left ventricle (LV) during high-risk percutaneous coronary interventions (HR-PCI) and in patients hospitalized with cardiogenic shock (CS). In the course of HR-PCI and CS, the LV may require support in pumping oxygenated blood from the ventricle into the aorta, so that adequate cardiac output, arterial blood pressure and coronary and end-organ perfusion could be maintained.

Heart failure (HF) is a pandemic affecting millions of people worldwide. Although the vast majority of hospitalizations for worsening HF are due to symptoms of congestion and volume overload, patients are frequently discharged with residual signs of congestion, which likely contribute to the consistently high readmission rates observed in acute decompensated heart failure (ADHF). The kidneys are the primary organs responsible for maintaining the body’s water and salt balance. As encapsulated organs, they are particularly vulnerable to congestion: cardiac dysfunction and fluid buildup/redistribution leads to increased central venous pressure, increased renal venous pressures and, ultimately, increased renal interstitial pressures. The latter result in decreased renal blood flow, glomerular filtration rate, urine output and sodium excretion.