Massive Photonics GmbH products

The MASSIVE-sdAB 1-PLEX Kit from Massive Photonics is designed for DNA-PAINT imaging applications, providing a camelid single-domain antibody (sdAB) to target mouse IgG kappa light chain or rabbit IgG. Engineered for precision, the sdAB is site-specifically coupled to a DNA-PAINT docking site, allowing for improved binding efficiency. This kit enhances imaging accuracy by reducing linkage errors while increasing protein accessibility. Secondary camelid sdABs are key to ensuring this reliability. Additionally, the kit includes necessary imager strands and buffers to facilitate comprehensive sample preparation and imaging activities. Its ability to enhance signal amplification through the binding of two sdABs per primary antibody sets new benchmarks in the accuracy of protein labeling, contributing to exceptional imaging resolution.

The FAST-DNA-PAINT Imaging Kits by Massive Photonics are designed for advanced cellular imaging applications. These kits offer ready-to-use binders for high-resolution FAST DNA-PAINT imaging, specifically catering to a variety of targets including mouse and rabbit IgG, GFP, PD-L1, CTLA-4, and neuronal proteins like Synaptotagmin-1 and VGLUT1. Each kit contains camelid single-domain antibodies (sdABs) that are conjugated to FAST sequences, enhancing the imaging process by significantly reducing acquisition times while boosting signal-to-noise ratios. FAST sequences permit efficient and accelerated imaging, making them ideal for applications requiring high throughput and precision. The kits also include essential imager strands and buffers for complete imaging workflows. Unmodified and fluorophore-labeled sdABs, known as FluoTag®, provide flexibility and are readily available from NanoTag. These kits are suitable for a range of applications, including immunostaining and super-resolution imaging of various biological samples.

The Primary Antibody Labeling Kit from Massive Photonics is designed for advanced FAST DNA-PAINT imaging, specifically targeting mouse IgG kappa light chain or rabbit IgG primary antibodies. This kit leverages camelid single-domain antibodies (sdABs) coupled to DNA-PAINT sites optimized for rapid imaging and high signal-to-noise ratios. The incorporation of FAST sequences significantly reduces image acquisition time by three times compared to standard methods. Each sdAB is engineered to attach precisely to a single FAST docking site, with two sdABs binding one primary antibody, providing dual docking sites per antibody. The secondary camelid sdABs' small size minimizes linkage error and enhances target protein accessibility. Compatible with both unmodified and fluorophore-coupled sdABs, the kit enhances imaging versatility. This technical solution is particularly beneficial for researchers employing the ONI Nanoimager microscope, aiming for precision and efficiency in cellular imaging applications.