Meissa Vaccines, Inc. products
AttenuBlock - Technology for Optimized Immunity
The attenuation of a virus to produce a vaccine must balance reducing its virulence while retaining its ability to stimulate an effective immune response, or immunogenicity. Natural RSV infection does not stimulate a robust immune response, and immunity following SARS-CoV-2 infection wanes, so vaccine technologies that enhance immunogenicity are required. AttenuBlock is Meissa`s proprietary platform that uses synthetic biology – the area of science focused on redesigning natural organisms to give them new abilities – to generate live attenuated RSV vaccine candidates designed to increase antigen expression and decrease or eliminate the expression genes that counteract the immune response.
Meissa - COVID-19 Live Attenuated Vaccine Candidate
Meissa is developing a live attenuated COVID-19 vaccine candidate, MV-014-212, to induce mucosal and systemic immunity and protect against SARS-CoV-2, the novel coronavirus that causes COVID-19. Like Meissa’s RSV vaccine candidate, MV-014-212 offers significant potential advantages for global deployment, including needle-free intranasal administration, a single adjuvant-free dose to induce mucosal and systemic immunity, as well as a straightforward, economical, and scalable manufacturing process. A Phase 1 clinical study has been initiated in the U.S. to evaluate the safety, tolerability, and immunogenicity of a single intranasal dose of MV-014-212 (ClinicalTrials.gov identifier: NCT04798001).
Live Attenuated Vaccines for Life-Threatening Respiratory Viruses
Respiratory viruses are one of the biggest threats to human health. Vaccines are the most effective healthcare tool to combat infectious diseases and have saved more lives than any other type of medicine. Meissa is dedicated to creating safe, potent, stable, and accessible intranasal live attenuated vaccines that can prevent infection and disease. Meissa’s RSV and COVID-19 live attenuated vaccine candidates were developed using the company’s AttenuBlock platform.
Meissa - RSV Live Attenuated Vaccine Candidate
Meissa is developing MV-012-968, an intranasal (needle-free), adjuvant-free, live attenuated vaccine candidate, to protect infants and at-risk, older adults from RSV. In Phase 1 clinical trials, Meissa’s RSV vaccine candidate was well-tolerated, heavily attenuated, and stimulated a strong RSV-specific mucosal IgA response in participants (adults and young children), who had previously been infected and already had circulating antibodies to RSV in their blood (ClinicalTrials.gov identifiers NCT04444284 and NCT04227210).